Research Papers: Sensing

Habits with killer instincts: in vivo analysis on the severity of oral mucosal alterations using autofluorescence spectroscopy

[+] Author Affiliations
S. Nazeer Shaiju, Saraswathy Ariya, Ramapurath S. Jayasree

Sree Chitra Tirunal Institute for Medical Sciences & Technology, Biophotonics and Molecular Imaging Lab, Biomedical Technology Wing, Poojappura, Thiruvananthapuram – 695 012, Kerala, India

Rajasekharan Asish

Government Dental College, Department of Oral Medicine & Radiology, Thiruvananthapuram – 695 011, Kerala, India

Government Dental College, Department of Oral Medicine & Radiology, Kottayam – 686 008 Kerala, India

Padippurakkakath Salim Haris, Balan Anita

Government Dental College, Department of Oral Medicine & Radiology, Thiruvananthapuram – 695 011, Kerala, India

Government Dental College, Department of Oral Medicine & Radiology, Kozhikkode – 673 008 Kerala, India

Gupta Arun Kumar

Sree Chitra Tirunal Institute for Medical Sciences & Technology, Department of Imaging Sciences and Interventional Radiology, Thiruvananthapuram – 695 011, Kerala, India

J. Biomed. Opt. 16(8), 087006 (August 09, 2011). doi:10.1117/1.3608923
History: Received March 14, 2011; Revised June 15, 2011; Accepted August 16, 2011; Published August 09, 2011; Online August 09, 2011
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Oral habits like chewing and smoking are main causes of oral cancer, which has a higher mortality rate than many other cancer forms. Currently, the long term survival rate of oral cancer is less than 50%, as a majority of cases are detected very late. The clinician's main challenge is to differentiate among a multitude of red, white, or ulcerated lesions. Hence, new noninvasive, reliable, and fast techniques for the discrimination of oral cavity disorders are to be developed. This study includes autofluorescence spectroscopic screening of normal volunteers with and without lifestyle oral habits and patients with oral submucous fibrosis (OSF). The spectra from different sites of habitués, non-habitués, and OSF patients were analyzed using the intensity ratio, redox ratio, and linear discriminant analysis (LDA). The spectral disparities among these groups are well demonstrated in the emission regions of collagen and Flavin adenine dinucleotide. We observed that LDA gives better efficiency of classification than the intensity ratio technique. Even the differentiation of habitués and non-habitués could be well established with LDA. The study concludes that the clinical application of autofluorescence spectroscopy along with LDA, yields spontaneous screening among individuals, facilitating better patient management for clinicians and better quality of life for patients.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

S. Nazeer Shaiju ; Saraswathy Ariya ; Rajasekharan Asish ; Padippurakkakath Salim Haris ; Balan Anita, et al.
"Habits with killer instincts: in vivo analysis on the severity of oral mucosal alterations using autofluorescence spectroscopy", J. Biomed. Opt. 16(8), 087006 (August 09, 2011). ; http://dx.doi.org/10.1117/1.3608923


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