Research Papers: Sensing

Correlation of functional and resting state connectivity of cerebral oxy-, deoxy-, and total hemoglobin concentration changes measured by near-infrared spectrophotometry

[+] Author Affiliations
Ursula Wolf

University of California, Irvine, Biomedical Engineering Department, Laboratory for Fluorescence Dynamics, 3120 Natural Sciences 2, Irvine, California 92697-2715

University of Bern, Institute of Complementary Medicine KIKOM, 3010 Bern, Switzerland

Vladislav Toronov

University of California, Irvine, Biomedical Engineering Department, Laboratory for Fluorescence Dynamics, 3120 Natural Sciences 2, Irvine, California 92697-2715

Ryerson University, Department of Physics, Toronto, Ontario, M5B 2K3 Canada

Jee H. Choi

University of California, Irvine, Biomedical Engineering Department, Laboratory for Fluorescence Dynamics, 3120 Natural Sciences 2, Irvine, California 92697-2715

Korea Institute of Science and Technology, Center for Neural Science, Seoul, Seoul 136-791, Republic of Korea

Rajarsi Gupta, Enrico Gratton

University of California, Irvine, Biomedical Engineering Department, Laboratory for Fluorescence Dynamics, 3120 Natural Sciences 2, Irvine, California 92697-2715

Antonios Michalos

University of California, Irvine, Biomedical Engineering Department, Laboratory for Fluorescence Dynamics, 3120 Natural Sciences 2, Irvine, California 92697-2715

University of Illinois at Urbana-Champaign, Center for Health Information Privacy and Security, Information Trust Institute, Urbana, Illinois 61801-2307

Martin Wolf

University of California, Irvine, Biomedical Engineering Department, Laboratory for Fluorescence Dynamics, 3120 Natural Sciences 2, Irvine, California 92697-2715

University Hospital Zurich, Neonatology, Biomedical Optics Research Laboratory, Zurich 8091 Switzerland

J. Biomed. Opt. 16(8), 087013 (August 19, 2011). doi:10.1117/1.3615249
History: Received March 12, 2011; Revised July 01, 2011; Accepted July 01, 2011; Published August 19, 2011; Online August 19, 2011
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The aim is to study cerebral vascular functional connectivity during motor tasks and resting state using multichannel frequency-domain near-infrared spectrophotometry. Maps of 5.7 × 10.8 cm size displaying changes in cerebral oxyhemoglobin (O2Hb), deoxyhemoglobin (HHb), and total hemoglobin (tHb) concentrations were measured in the motor cortex in 12 subjects (mean age of 28.8±12.7 yrs) during resting state and during two palm squeezing tasks with different timing. For each condition, phase plane plots, cross correlation functions, and connectivity indices were generated for O2Hb, HHb, and tHb. The amplitude of the concentration changes in O2Hb and HHb depends on the age of the subject. We found large regions of connectivity, which were similar for resting state and task conditions. This means the spatial relationships during resting state, when changes in O2Hb, HHb, and tHb corresponded to spontaneous oscillations, were correlated to the spatial patterns during the activation tasks, when changes in O2Hb, HHb, and tHb concentration were related to the alternation of stimulation and rest. Thus, the vascular functional connectivity was also present during resting state. The findings suggest that the vascular response to functional activation may be a nonlinear synchronization phenomenon and that resting state processes are more important than previously expected.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Ursula Wolf ; Vladislav Toronov ; Jee H. Choi ; Rajarsi Gupta ; Antonios Michalos, et al.
"Correlation of functional and resting state connectivity of cerebral oxy-, deoxy-, and total hemoglobin concentration changes measured by near-infrared spectrophotometry", J. Biomed. Opt. 16(8), 087013 (August 19, 2011). ; http://dx.doi.org/10.1117/1.3615249


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