Research Papers: Imaging

Optical coherent tomography: promising in vivo measurement of hair shaft cross section

[+] Author Affiliations
Natalie Garcia Bartels

Charité-Universitätsmedizin Berlin, Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité Campus Mitte, Charitéplatz 1, Berlin, 10117 Germany

Charité-Universitätsmedizin Berlin, Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology and Allergy, Charité Campus Mitte, Charitéplatz 1, Berlin, 10117 Germany

Karola Stieler, Ulrike Blume-Peytavi

Charité-Universitätsmedizin Berlin, Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité Campus Mitte, Charitéplatz 1, Berlin, 10117 Germany

Heike Richter, Alexa Patzelt, Jürgen Lademann

Charité-Universitätsmedizin Berlin, Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology and Allergy, Charité Campus Mitte, Charitéplatz 1, Berlin, 10117 Germany

J. Biomed. Opt. 16(9), 096003 (September 21, 2011). doi:10.1117/1.3626210
History: Received February 22, 2011; Revised April 20, 2011; Accepted July 06, 2011; Published September 21, 2011; Online September 21, 2011
Text Size: A A A

Variations in hair shaft morphology reflect ethnical diversity, but may also indicate internal diseases, nutritional deficiency, or hair and scalp disorders. The measurement and the follow-up of the hair shaft thickness over a defined period of time would be a valuable diagnostic tool in clinical practice. Standard light microscopy (LM) measurements require the epilation of hair shafts and frequently yield inaccurate values caused by the elliptic geometry of human hair shafts. Optical coherence tomography (OCT) is a noninvasive investigation method based on the principles of Michelson interferometry with a detection depth of approximately 1 mm in human skin. Two-dimensional images of the cross sections of tissue samples at a resolution of approximately 10 μm are produced, which allows convenient calculation of hair shaft thickness. To evaluate this new methodology for hair shaft thickness measurements, hair shafts taken from 28 healthy volunteers were analyzed by in vivo OCT and compared to standard in vitro LM measurements of hair shaft thickness. OCT yielded highly reproducible measurements of hair shaft thickness with a distinctly reduced variation compared to standard LM. This technique offers a unique opportunity for in vivo measurement and a follow-up of the kinetics of hair shaft thickness in humans during medical therapy.

Figures in this Article
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Natalie Garcia Bartels ; Karola Stieler ; Heike Richter ; Alexa Patzelt ; Jürgen Lademann, et al.
"Optical coherent tomography: promising in vivo measurement of hair shaft cross section", J. Biomed. Opt. 16(9), 096003 (September 21, 2011). ; http://dx.doi.org/10.1117/1.3626210


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.