Research Papers: Imaging

Automated determination of cup-to-disc ratio for classification of glaucomatous and normal eyes on stereo retinal fundus images

[+] Author Affiliations
Chisako Muramatsu, Hiroshi Fujita

Gifu University, Graduate School of Medicine, Department of Intelligent Image Information 1-1 Yanagido, Gifu 501-1194, Japan

Toshiaki Nakagawa

Kowa Company, Ltd., Electronics and Optics Division, Research & Development Section, Hamamatsu Factory, 1-3-1 Shin-Miyakoda, Kita-ku, Hamamatsu-shi, Shizuoka 431-2103, Japan

Akira Sawada, Tetsuya Yamamoto

Gifu Universtiy, Graduate School of Medicine, Department of Ophthalmology, 1-1 Yanagido, Gifu 501-1194, Japan

Yuji Hatanaka

University of Shiga Prefecture, School of Engineering, Department of Electronic System Engineering, 2500 Hassakacho, Hikone, Shiga 522-8533, Japan

J. Biomed. Opt. 16(9), 096009 (September 02, 2011). doi:10.1117/1.3622755
History: Received January 20, 2011; Accepted July 18, 2011; Published September 02, 2011; Online September 02, 2011
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Early diagnosis of glaucoma, which is the second leading cause of blindness in the world, can halt or slow the progression of the disease. We propose an automated method for analyzing the optic disc and measuring the cup-to-disc ratio (CDR) on stereo retinal fundus images to improve ophthalmologists’ diagnostic efficiency and potentially reduce the variation on the CDR measurement. The method was developed using 80 retinal fundus image pairs, including 25 glaucomatous, and 55 nonglaucomatous eyes, obtained at our institution. A disc region was segmented using the active contour method with the brightness and edge information. The segmentation of a cup region was performed using a depth map of the optic disc, which was reconstructed on the basis of the stereo disparity. The CDRs were measured and compared with those determined using the manual segmentation results by an expert ophthalmologist. The method was applied to a new database which consisted of 98 stereo image pairs including 60 and 30 pairs with and without signs of glaucoma, respectively. Using the CDRs, an area under the receiver operating characteristic curve of 0.90 was obtained for classification of the glaucomatous and nonglaucomatous eyes. The result indicates potential usefulness of the automated determination of CDRs for the diagnosis of glaucoma.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Chisako Muramatsu ; Toshiaki Nakagawa ; Akira Sawada ; Yuji Hatanaka ; Tetsuya Yamamoto, et al.
"Automated determination of cup-to-disc ratio for classification of glaucomatous and normal eyes on stereo retinal fundus images", J. Biomed. Opt. 16(9), 096009 (September 02, 2011). ; http://dx.doi.org/10.1117/1.3622755


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