Research Papers: Sensing

Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants

[+] Author Affiliations
Carmen Jenny, Jean-Claude Fauchère, Hans Ulrich Bucher, Martin Wolf

University Hospital Zurich, Biomedical Optics Research Laboratory, Division of Neonatology, Department of Obstetrics and Gynecology, 8091 Zurich, Switzerland

Martin Biallas, Ivo Trajkovic

University Hospital Zurich, Biomedical Optics Research Laboratory, Division of Neonatology, Department of Obstetrics and Gynecology, 8091 Zurich, Switzerland

University of Zurich and ETH Zurich, Institute for Biomedical Engineering, 8093 Zurich, Switzerland

J. Biomed. Opt. 16(9), 097004 (September 02, 2011). doi:10.1117/1.3622756
History: Received April 04, 2011; Revised June 28, 2011; Accepted July 18, 2011; Published September 02, 2011; Online September 02, 2011
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Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the cerebral tissue oxygen saturation (StO2) measured by near-infrared spectroscopy (NIRS). So far the reproducibility of StO2 measurements was too low for clinical application, probably due to inhomogeneities. The aim of this study was to test a novel sensor geometry which reduces the influence of inhomogeneities. Thirty clinically stable newborn infants, with a gestational age of median 33.9 (range 26.9 to 41.9) weeks, birth weight of 2220 (820 to 4230) g, postnatal age of 5 (1 to 71) days were studied. At least four StO2 measurements of 1 min duration were carried out using NIRS on the lateral head. The sensor was repositioned between measurements. Reproducibility was calculated by a linear mixed effects model. The mean StO2 was 79.99 ± 4.47% with a reproducibility of 2.76% and a between-infant variability of 4.20%. Thus, the error of measurement only accounts for 30.1% of the variability. The novel sensor geometry leads to considerably more precise measurements compared to previous studies with, e.g., ∼5% reproducibility for the NIRO 300. The novel StO2 values hence have a higher clinical relevance.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Carmen Jenny ; Martin Biallas ; Ivo Trajkovic ; Jean-Claude Fauchère ; Hans Ulrich Bucher, et al.
"Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants", J. Biomed. Opt. 16(9), 097004 (September 02, 2011). ; http://dx.doi.org/10.1117/1.3622756


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