Research Papers: Therapeutic

Choosing optimal wavelength for photodynamic therapy of port wine stains by mathematic simulation

[+] Author Affiliations
Ying Wang, Ying Gu, Zhaohui Zuo, Naiyan Huang

Chinese People's Liberation Army General Hospital, Department of Laser Medicine, Beijing 100853, China

J. Biomed. Opt. 16(9), 098001 (September 01, 2011). doi:10.1117/1.3616127
History: Received March 23, 2011; Revised July 02, 2011; Accepted July 07, 2011; Published September 01, 2011; September 27, 2011; Online September 01, 2011
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Many laser wavelengths have been used in photodynamic therapy (PDT) for port wine stains (PWS). However, how these wavelengths result in different PDT outcomes has not been clearly illuminated. This study is designed to analyze which wavelengths would be the most advantageous for use in PDT for PWS. The singlet oxygen yield in PDT-treated PWS skin under different wavelengths at the same photosensitizer dosage was simulated and the following three situations were simulated and compared: 1. PDT efficiency of 488, 532, 510, 578, and 630 nm laser irradiation at clinical dosage (100 mW/cm2, 40 min); 2. PDT efficiency of different wavelength for PWS with hyperpigmentation after previous PDT; 3. PDT efficiency of different wavelengths for PWS, in which only deeply located ectatic vessels remained. The results showed that singlet oxygen yield is the highest at 510 nm, it is similar at 532 nm and 488 nm, and very low at 578 nm and 630 nm. This result is identical to the state in clinic. According to this theoretical study, the optimal wavelength for PDT in the treatment of PWS should near the absorption peaks of photosensitizer and where absorption from native chromophores (haemoglobin and melanin) is diminished.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Ying Wang ; Ying Gu ; Zhaohui Zuo and Naiyan Huang
"Choosing optimal wavelength for photodynamic therapy of port wine stains by mathematic simulation", J. Biomed. Opt. 16(9), 098001 (September 01, 2011). ; http://dx.doi.org/10.1117/1.3616127


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