Research Papers: Imaging

Beyond the lateral resolution limit by phase imaging

[+] Author Affiliations
Yann Cotte, M. Fatih Toy, Christian Depeursinge

Ecole Polytechnique Fédérale de Lausanne (EPFL), Microvision and Microdiagnostics Group (MVD), Lausanne, 1015, Switzerland

J. Biomed. Opt. 16(10), 106007 (October 07, 2011). doi:10.1117/1.3640812
History: Received April 04, 2011; Revised July 29, 2011; Accepted August 29, 2011; Published October 07, 2011; Online October 07, 2011
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We present a theory to extend the classical Abbe resolution limit by introducing a spatially varying phase into the illumination beam of a phase imaging system. It allows measuring lateral and axial distance differences between point sources to a higher accuracy than intensity imaging alone. Various proposals for experimental realization are debated. Concretely, the phase of point scatterers’ interference is experimentally visualized by high numerical aperture (NA = 0.93) digital holographic microscopy combined with angular scanning. Proof-of-principle measurements are presented by using sub-wavelength nanometric holes on an opaque metallic film. In this manner, Rayleighs classical two-point resolution condition can be rebuilt. With different illumination phases, enhanced bandpass information content is demonstrated, and its spatial resolution is theoretically shown to be potentially signal-to-noise ratio limited.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Yann Cotte ; M. Fatih Toy and Christian Depeursinge
"Beyond the lateral resolution limit by phase imaging", J. Biomed. Opt. 16(10), 106007 (October 07, 2011). ; http://dx.doi.org/10.1117/1.3640812


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