Research Papers: Imaging

Reduction of image artifacts in three-dimensional optical coherence tomography of skin in vivo

[+] Author Affiliations
Yih Miin Liew, Robert A. McLaughlin

The University of Western Australia, School of Electrical, Electronic & Computer Engineering, Optical+Biomedical Engineering Laboratory, M018, 35 Stirling Highway, Crawley WA 6009, Australia

Fiona M. Wood

Royal Perth Hospital, Burns Service of Western Australia, Wellington Street, Perth WA 6000, Australia

The University of Western Australia, School of Surgery, Burn Injury Research Unit, 35 Stirling Highway, Crawley WA 6009, Australia

David D. Sampson

The University of Western Australia, School of Electrical, Electronic & Computer Engineering, Optical+Biomedical Engineering Laboratory, M018, 35 Stirling Highway, Crawley WA 6009, Australia

The University of Western Australia, Centre for Microscopy, Characterisation & Analysis, M010, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia

J. Biomed. Opt. 16(11), 116018 (November 03, 2011). doi:10.1117/1.3652710
History: Received May 09, 2011; Revised September 09, 2011; Accepted September 23, 2011; Published November 03, 2011; Online November 03, 2011
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This paper presents results of in vivo studies on the effect of refractive index-matching media on image artifacts in optical coherence tomography (OCT) images of human skin. These artifacts present as streaks of artificially low backscatter and displacement or distortion of features. They are primarily caused by refraction and scattering of the OCT light beam at the skin surface. The impact of the application of glycerol and ultrasound gel is assessed on both novel skin-mimicking phantoms and in vivo human skin, including assessment of the epidermal thickening caused by the media. Based on our findings, recommendations are given for optimal OCT imaging of skin in vivo.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Yih Miin Liew ; Robert A. McLaughlin ; Fiona M. Wood and David D. Sampson
"Reduction of image artifacts in three-dimensional optical coherence tomography of skin in vivo", J. Biomed. Opt. 16(11), 116018 (November 03, 2011). ; http://dx.doi.org/10.1117/1.3652710


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