Research Papers: Imaging

Impact of contralateral and ipsilateral reference tissue selection on self-referencing differential spectroscopy for breast cancer detection

[+] Author Affiliations
Anaïs Leproux, Albert E. Cerussi, Wendy Tanamai, Amanda F. Durkin, Montana Compton, Bruce J. Tromberg

University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612

Enrico Gratton

University of California, Irvine, Laboratory for Fluorescence Dynamics, Irvine, California 92612

J. Biomed. Opt. 16(11), 116019 (November 02, 2011). doi:10.1117/1.3652711
History: Received June 24, 2011; Revised September 21, 2011; Accepted September 23, 2011; Published November 02, 2011; Online November 02, 2011
Text Size: A A A

We previously developed a self-referencing differential spectroscopic (SRDS) method to detect lesions by identifying a spectroscopic biomarker of breast cancer, i.e., the specific tumor component (STC). The SRDS method is based on the assumption of the exclusive presence of this spectroscopic biomaker in malignant disease. Although clinical results using this method have already been published, the dependence of the STC spectra on the choice of reference tissue has not yet been addressed. In this study, we explore the impact of the selection of the reference region size and location on the STC spectrum in 10 subjects with malignant breast tumors. Referencing from both contralateral and ipsilateral sides was performed. Regardless of the referencing, we are able to obtain consistent high contrast images of malignant lesions using the STC with less than 13% deviation. These results suggest that the STC measurements are independent of any type, location, and amount of normal breast tissue used for referencing. This confirms the initial assumption of the SRDS analysis, that there are specific tumor components in cancer that do not exist in normal tissue. This also indicates that bilateral measurements are not required for lesion identification using the STC method.

Figures in this Article
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Anaïs Leproux ; Albert E. Cerussi ; Wendy Tanamai ; Amanda F. Durkin ; Montana Compton, et al.
"Impact of contralateral and ipsilateral reference tissue selection on self-referencing differential spectroscopy for breast cancer detection", J. Biomed. Opt. 16(11), 116019 (November 02, 2011). ; http://dx.doi.org/10.1117/1.3652711


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.