Research Papers: Sensing

Optical spectroscopy combined with high-resolution magnetic resonance imaging for digestive wall assessment: endoluminal bimodal probe conception and characterization in vitro, on organic sample and in vivo on a rabbit

[+] Author Affiliations
Anoop Ramgolam, Raphaël Sablong, Olivier Beuf

Université de Lyon, INSA-Lyon CREATIS, CNRS UMR 5220, Inserm U1044, France

Lionel Lafarge

Université de Lyon, CNRS INSA-Lyon, LaMCoS, UMR5259, F-69621, France

Hervé Saint-Jalmes

LTSI, Inserm U642, Université Rennes 1, CRLCC, Centre Eugene Marquis, Rennes, France

J. Biomed. Opt. 16(11), 117005 (October 28, 2011). doi:10.1117/1.3646917
History: Received July 22, 2011; Revised September 15, 2011; Accepted September 16, 2011; Published October 28, 2011; Online October 28, 2011
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Colorectal cancer is a major health issue worldwide. Conventional white light endoscopy (WLE) coupled to histology is considered as the gold standard today and is the most widespread technique used for colorectal cancer diagnosis. However, during the early stages, colorectal cancer is very often characterized by flat adenomas which develop just underneath the mucosal surface. The use of WLE, which is heavily based on the detection of morphological changes, becomes quite delicate due to subtle or quasi-invisible morphological changes of the colonic lining. Several techniques are currently being investigated in the scope of providing new tools that would allow such a diagnostic or assist actual techniques in so doing. We hereby present a novel technique where high spatial resolution MRI is combined with autofluorescence and reflectance spectroscopy in a bimodal endoluminal probe to extract morphological data and biochemical information, respectively. The design and conception of the endoluminal probe are detailed and the promising preliminary results obtained in vitro (home-built phantom containing eosin and rhodamine B), on an organic sample (the kiwi fruit) and in vivo on a rabbit are presented and discussed.

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Anoop Ramgolam ; Raphaël Sablong ; Lionel Lafarge ; Hervé Saint-Jalmes and Olivier Beuf
"Optical spectroscopy combined with high-resolution magnetic resonance imaging for digestive wall assessment: endoluminal bimodal probe conception and characterization in vitro, on organic sample and in vivo on a rabbit", J. Biomed. Opt. 16(11), 117005 (October 28, 2011). ; http://dx.doi.org/10.1117/1.3646917


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