Research Papers: Imaging

Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography

[+] Author Affiliations
Guangying Guan

University of Washington, Department of Bioengineering, 3720 15th Avenue N. E., Seattle, Washington 98195

University of Dundee, Division of Mechanical Engineering and Mechatronics, Dundee DD1 4HN, Scotland, United Kingdom

Roberto Reif, Ruikang K. Wang

University of Washington, Department of Bioengineering, 3720 15th Avenue N. E., Seattle, Washington 98195

Zhihong Huang

University of Dundee, Division of Mechanical Engineering and Mechatronics, Dundee DD1 4HN, Scotland, United Kingdom

J. Biomed. Opt. 16(12), 126003 (November 28, 2011). doi:10.1117/1.3659211
History: Received August 16, 2011; Revised October 11, 2011; Accepted October 19, 2011; Published November 28, 2011; Online November 28, 2011
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A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography system, which detects the changes in the optical path length of the sample induced by the temperature increase. The model is theoretically derived and the coefficients are empirically determined using solid homogeneous gel phantoms. The model is validated by reconstructing the concentration of a photothermal compound in thick single and double layer solid phantoms.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Guangying Guan ; Roberto Reif ; Zhihong Huang and Ruikang K. Wang
"Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography", J. Biomed. Opt. 16(12), 126003 (November 28, 2011). ; http://dx.doi.org/10.1117/1.3659211


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