Research Papers: Imaging

Noncontact common-path Fourier domain optical coherence tomography method for in vitro intraocular lens power measurement

[+] Author Affiliations
Yong Huang

U.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993

Johns Hopkins University, Department of Electrical and Computer Engineering, 3400 N. Charles Street, Baltimore, Maryland 21218

Kang Zhang

GE Global Research, 1 Research Circle, Niskayuna, New York 12309

Jin U. Kang

Johns Hopkins University, Department of Electrical and Computer Engineering, 3400 N. Charles Street, Baltimore, Maryland 21218

Don Calogero, Robert H. James, Ilko K. Ilev

U.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993

J. Biomed. Opt. 16(12), 126005 (November 23, 2011). doi:10.1117/1.3660313
History: Received May 23, 2011; Revised September 27, 2011; Accepted October 24, 2011; Published November 23, 2011; Online November 23, 2011
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We propose a novel common-path Fourier domain optical coherence tomography (CP-FD-OCT) method for noncontact, accurate, and objective in vitro measurement of the dioptric power of intraocular lenses (IOLs) implants. The CP-FD-OCT method principle of operation is based on simple two-dimensional scanning common-path Fourier domain optical coherence tomography. By reconstructing the anterior and posterior IOL surfaces, the radii of the two surfaces, and thus the IOL dioptric power are determined. The CP-FD-OCT design provides high accuracy of IOL surface reconstruction. The axial position detection accuracy is calibrated at 1.22 μm in balanced saline solution used for simulation of in situ conditions. The lateral sampling rate is controlled by the step size of linear scanning systems. IOL samples with labeled dioptric power in the low-power (5D), mid-power (20D and 22D), and high-power (36D) ranges under in situ conditions are tested. We obtained a mean power of 4.95/20.11/22.09/36.25 D with high levels of repeatability estimated by a standard deviation of 0.10/0.18/0.2/0.58 D and a relative error of 2/0.9/0.9/1.6%, based on five measurements for each IOL respectively. The new CP-FD-OCT method provides an independent source of IOL power measurement data as well as information for evaluating other optical properties of IOLs such as refractive index, central thickness, and aberrations.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Yong Huang ; Kang Zhang ; Jin U. Kang ; Don Calogero ; Robert H. James, et al.
"Noncontact common-path Fourier domain optical coherence tomography method for in vitro intraocular lens power measurement", J. Biomed. Opt. 16(12), 126005 (November 23, 2011). ; http://dx.doi.org/10.1117/1.3660313


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