Research Papers: Imaging

Optical imaging of alpha emitters: simulations, phantom, and in vivo results

[+] Author Affiliations
Federico Boschi, Andrea Sbarbati

University of Verona Department of Neurological, Neuropsychological, Morphological and Motor Sciences, Strada Le Grazie 8, 37134 Verona, Italy

Sergio Lo Meo

Ionizing Radiation Laboratory, National Institution for Insurance against Accidents at Work (INAIL), Via Fontana Candida 1, I-00040, Monte Porzio Catone, Rome, Italy

Pier Luca Rossi

University of Bologna, Department of Physics, Viale Berti Pichat 6/2, Bologna, Italy

Riccardo Calandrino, Antonello E. Spinelli

San Raffaele Scientific Institute, Medical Physics Department, Via Olgettina N. 60, Milan, Italy

J. Biomed. Opt. 16(12), 126011 (December 01, 2011). doi:10.1117/1.3663441
History: Received October 18, 2011; Revised October 28, 2011; Accepted November 02, 2011; Published December 01, 2011; Online December 01, 2011
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There has been growing interest in investigating both the in vitro and in vivo detection of optical photons from a plethora of beta emitters using optical techniques. In this paper we have investigated an alpha particle induced fluorescence signal by using a commercial CCD-based small animal optical imaging system. The light emission of a 241Am source was simulated using GEANT4 and tested in different experimental conditions including the imaging of in vivo tissue. We believe that the results presented in this work can be useful to describe a possible mechanism for the in vivo detection of alpha emitters used for therapeutic purposes.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Federico Boschi ; Sergio Lo Meo ; Pier Luca Rossi ; Riccardo Calandrino ; Andrea Sbarbati, et al.
"Optical imaging of alpha emitters: simulations, phantom, and in vivo results", J. Biomed. Opt. 16(12), 126011 (December 01, 2011). ; http://dx.doi.org/10.1117/1.3663441


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