Research Papers: Therapeutic

Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method

[+] Author Affiliations
Kelvin Le, Daniel Figueroa, Wei R. Chen

University of Central Oklahoma, Department of Engineering and Physics, Edmond, Oklahoma 73034

Xiaosong Li

University of Central Oklahoma, Department of Engineering and Physics, Edmond, Oklahoma 73034

The First Affiliated Hospital of Chinese PLA General Hospital, The Second Department of Oncology, Beijing 100048, China

Chinese PLA General Hospital, Department of Laser Medicine, Beijing 100853, China

Rheal A. Towner, Philippe Garteiser, Debra Saunders, Nataliya Smith

Oklahoma Medical Research Foundation, Advanced Magnetic Resonance Center, 825 NE 13th Street, Oklahoma City, Oklahoma 73104

Hong Liu

University of Oklahoma, Center for Bioengineering and School of Electrical and Computer Engineering, Norman, Oklahoma 73019

Tomas Hode, Robert E. Nordquist

ImmunoPhotonics Inc., Columbia, Missouri 65211

J. Biomed. Opt. 16(12), 128001 (December 05, 2011). doi:10.1117/1.3659200
History: Received July 13, 2011; Revised October 18, 2011; Accepted October 19, 2011; Published December 05, 2011; Online December 05, 2011
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Laser immunotherapy (LIT) uses a synergistic approach to treat cancer systemically through local laser irradiation and immunological stimulation. Currently, LIT utilizes dye-assisted noninvasive laser irradiation to achieve selective photothermal interaction. However, LIT faces difficulties treating deeper tumors or tumors with heavily pigmented overlying skin. To circumvent these barriers, we use interstitial laser irradiation to induce the desired photothermal effects. The purpose of this study is to analyze the thermal effects of interstitial irradiation using proton resonance frequency (PRF). An 805-nm near-infrared laser with an interstitial cylindrical diffuser was used to treat rat mammary tumors. Different power settings (1.0, 1.25, and 1.5 W) were applied with an irradiation duration of 10 min. The temperature distributions of the treated tumors were measured by a 7 T magnetic resonance imager using PRF. We found that temperature distributions in tissue depended on both laser power and time settings, and that variance in tissue composition has a major influence in temperature elevation. The temperature elevations measured during interstitial laser irradiation by PRF and thermocouple were consistent, with some variations due to tissue composition and the positioning of the thermocouple's needle probes. Our results indicated that, for a tissue irradiation of 10 min, the elevation of rat tumor temperature ranged from 8 to 11°C for 1 W and 8 to 15°C for 1.5 W. This is the first time a 7 T magnetic resonance imager has been used to monitor interstitial laser irradiation via PRF. Our work provides a basic understanding of the photothermal interaction needed to control the thermal damage inside a tumor using interstitial laser treatment. Our work may lead to an optimal protocol for future cancer treatment using interstitial phototherapy in conjunction with immunotherapy.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Kelvin Le ; Xiaosong Li ; Daniel Figueroa ; Rheal A. Towner ; Philippe Garteiser, et al.
"Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method", J. Biomed. Opt. 16(12), 128001 (December 05, 2011). ; http://dx.doi.org/10.1117/1.3659200


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