Research Papers: Sensing

Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy

[+] Author Affiliations
Yusuke Suzuki, Katsuhiko Maruo

Panasonic Electric Works Co., Ltd., Advanced Technologies Development Laboratory, 1048, Kadoma Kadoma-city, Osaka 571-8686, Japan

Alice W. Zhang

University of British Columbia, Department of Psychology, 2029—2136 West Mall, Vancouver, British Columbia V6T 1Z4, Canada

Kazushige Shimogaki, Hideto Ogawa, Fumiya Hirayama

Osaka Red Cross Blood Center, 2-4-43, Morinomiya Jyotouku Osaka-city, Osaka 536-0025, Japan

J. Biomed. Opt. 17(1), 017004 (Feb 07, 2012). doi:10.1117/1.JBO.17.1.017004
History: Received August 30, 2011; Revised November 21, 2011; Accepted November 28, 2011
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Abstract.  Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components. Hence this study is aimed to serve as a preliminary study for the nondestructive measurement of glucose level in transfusion blood. The glucose concentrations in red blood cell (RBC) samples were predicted using near-infrared diffuse-reflectance spectroscopy in the 1350 to 1850 nm wavelength region. Furthermore, the effects of donor, hematocrit level, and temperature variations among the RBC samples were observed. Results showed that the prediction performance of a dataset which contained samples that differed in all three parameters had a standard error of 29.3mg/dL. Multiplicative scatter correction (MSC) preprocessing method was also found to be effective in minimizing the variations in scattering patterns created by various sample properties. The results suggest that the diffuse-reflectance spectroscopy may provide another avenue for the detection of bacterial contamination in red cell concentrations (RCC) products.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Yusuke Suzuki ; Katsuhiko Maruo ; Alice W. Zhang ; Kazushige Shimogaki ; Hideto Ogawa, et al.
"Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy", J. Biomed. Opt. 17(1), 017004 (Feb 07, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.1.017004


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