Research Papers: Imaging

Angiography with a multifunctional line scanning ophthalmoscope

[+] Author Affiliations
Daniel X. Hammer, R. Daniel Ferguson, Ankit H. Patel

Physical Sciences Inc., 20 New England Business Center, Andover, Massachusetts 01810

Vanessa Vazquez, Deeba Husain

Boston University School of Medicine, Department of Ophthalmology, Boston, Massachusetts 02114

J. Biomed. Opt. 17(2), 026008 (Mar 13, 2012). doi:10.1117/1.JBO.17.2.026008
History: Received October 19, 2011; Revised December 14, 2011; Accepted December 15, 2011
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Abstract.  A multifunctional line scanning ophthalmoscope (mLSO) was designed, constructed, and tested on human subjects. The mLSO could sequentially acquire wide-field, confocal, near-infrared reflectance, fluorescein angiography (FA), and indocyanine green angiography (ICGA) retinal images. The system also included a retinal tracker (RT) and a photodynamic therapy laser treatment port. The mLSO was tested in a pilot clinical study on human subjects with and without retinal disease. The instrument exhibited robust retinal tracking and high-contrast line scanning imaging. The FA and ICGA angiograms showed a similar appearance of hyper- and hypo-pigmented disease features and a nearly equivalent resolution of fine capillaries compared to a commercial flood-illumination fundus imager. An mLSO-based platform will enable researchers and clinicians to image human and animal eyes with a variety of modalities and deliver therapeutic beams from a single automated interface. This approach has the potential to improve patient comfort and reduce imaging session times, allowing clinicians to better diagnose, plan, and conduct patient procedures with improved outcomes.

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© 2012 Society of Photo-Optical Instrumentation Engineers


Daniel X. Hammer ; R. Daniel Ferguson ; Ankit H. Patel ; Vanessa Vazquez and Deeba Husain
"Angiography with a multifunctional line scanning ophthalmoscope", J. Biomed. Opt. 17(2), 026008 (Mar 13, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.2.026008

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