Initially, MMM utilized microlenses or cascaded beamsplitter arrays to generate the multifocal array,3,4 and the scanning was achieved using galvo scanners. Recently, a spinning disk with microlenses has been used to construct an MMM; it achieved an imaging rate of up to 1000 frames per second (fps).3 However, with the combination of microlenses and galvo mirrors, there is a loss of incident power of nearly 75%.5 Using the spinning disk with microlenses also causes an unavoidable loss of power from beam expansion and optical trains. In addition, the nonuniformity of probe intensity in these systems causes the peripheral regions of the image to be 50% less intense than the center.3 More recently, a miniature, low-cost diffractive optical element (DOE) in tandem with galvo scanners has been applied to produce an array of up to focal points with a diffraction efficiency of 75% and uniformity in focal intensity within 1%.6 With this DOE system, an MMM that is 1000-fold faster than a conventional single-beam multiphoton microscope is achieved using stochastic scanning.7 When the entire FOV is scanned with an MMM, the imaging rate increases as the number of beamlets increase. However, with the increase of the number of beamlets, the power of each beamlet decreases, resulting in a low signal to noise ratio. Therefore total available power, which is determined by the laser and the damage threshold of the optics [e.g., the spatial light modulator (SLM)] used in the system, limits the number of beamlets and thus the image rate. In some applications, however, only a small area of the FOV contains the features that must be rapidly imaged with high resolution. For example, when studying a sarcomere’s contraction, we first locate a target muscle cell in the FOV. We then focus the image system into this cell body to acquire high resolution images of the sarcomere at a very high rate that freezes the contraction. In such cases, a small number of beamlets can be used to scan the FOV with low speed and resolution and then scan the area(s) of interest selected rapidly with high resolution. A SLM can be used to realize this addressable multifocal imaging concept. Scanless microscopy has been developed using a SLM, which distributes the illumination light dynamically into multiple areas of interest.8 In scanless SLM microscopy, however, a lack of the confocal gate for 3D sectioning and multiphoton excitation occurs when an entire area of interest is simultaneously illuminated.