In a next step, sensitivity and specificity of all four caries detection systems were calculated. As cutoff point, the corresponding value for ICDAS grouping of score 0, 1, and 2 together as healthy and noncavitated lesions was chosen (Figs. 2728–29). Table 4 shows in addition to the average scores () for each diagnostic method for the grouping of code 1, 2, and 3 together as overview the average values for ICDAS code 1, 2, and 3, separately. If the value for grouping ICDAS code 0, 1, and 2 is chosen as cutoff point for the sensitivity calculation, the average value for DIAGNOdent is 15.5 with a corresponding sensitivity of 87% and a specificity of 66%. With the same ICDAS cutoff, Spectra Caries Detection Aid at its corresponding cutoff value of 1.3 achieves a sensitivity of 92%, but the specificity is only 37%. SOPROLIFE in daylight mode with an equivalent cutoff value of 1.54 presents a sensitivity of 93% and specificity of 63%, while SOPROLIFE blue fluorescence with cutoff value of 1.52 shows a sensitivity of 95%, but the specificity is down to 55%. Table 5 summarizes the specific tool cutoff values for grouping ICDAS 0 with 1 and 2 as “healthy,” the sensitivity and specificity at this cutoff, confidence intervals, and likelihood ratio.