Hyperthermia has been studied as a choice for cancer treatments with various heating sources, such as microwaves, focused ultrasound waves, radio waves, and NIR lasers.10,11,18 Here we report the feasibility of using PIN as a thermal therapy agent to greatly induce local heating. We inserted thermocouple wires (Omega Technologies Inc., Stamford, CT) 3, 5, and 7 mm, respectively, below the top surface of the phantom for depth measurements as well as 3, 5, and 7 mm laterally away from the laser tip for distance measurements, as shown in Fig. 3(a) to 3(c). The temperature was continuously recorded using a data logger (Hydra Fluke). A continuous-wave laser at 808 nm (Coherent Inc., Santa Clara, CA) was used, irradiating the phantom about an area of on the top surface of phantoms. The irradiated area was calculated from the numerical aperture of the fiber (0.22), diameter of the fiber (800 µm), and the distance between the laser fiber and phantom (2 mm). The laser power was set at 0.8 W, and the phantom was continuously irradiated for 5 min. The transient temperature changes were monitored at every 5 sec during the entire irradiation period (i.e., 5 min) for control ICG as well as PIN phantoms with different concentrations in order to monitor the thermal changes of ICG and PIN samples with respect to the control sample.