When the human eye ages and is affected by presbyopia, it gradually loses accommodation, i.e., the capability to form images of objects placed at different distances; beyond the age of about 50, the human eye becomes a system with a fixed focal length.5 Traditional solutions to the problem consist of multifocal lenses in a variety of compound refractive and diffractive designs and categories (spectacles, contact, and intraocular lenses). They are not fully satisfactory but a discrete solution that ensures, at least, a couple of focused images (named near and far powers) for two (near and far) positions of an object. Bifocal and progressive spectacle lenses are widely used still today as well as bifocal and multifocal contact lenses, the latter with less success though. The application of multifocal designs to the intraocular lenses conventionally used in cataract surgery has opened a new possibility for the simultaneous compensation of defocus and presbyopia (for a short review see, for instance, 6). Since a monofocal intraocular lens only provides clear vision for a very limited depth of field, surgeons prescribe an additional corrective lens for either distance or near vision. Multifocal intraocular lenses are designed to reduce the dependence on spectacles. They are mostly bifocal, although trifocal designs have been reported too.7 Multifocal intraocular lenses address the lack of accommodation using the principle of simultaneous vision and brain adaptation, which implies to choose between the near and distance images, both superimposed on the retina, depending on the object at which the observer is looking. The superposition of images may lead to rivalry or confusion, often associated with other unpleasant visual phenomena, such as glare and halos, in mesopic and scotopic conditions. These multifocal lenses can be classified according two basic designs, named refractive and diffractive.8 Refractive multifocal intraocular lenses are multizone lenses with either concentric arrangement or circular asymmetry.9 A diffractive multifocal intraocular lens uses the base lens curvature and the zeroth and first diffraction orders to simultaneously produce the two focal points.10 While the power corresponding to the zeroth diffraction order is used to image distance objects, the first order is used for near vision. Some designs of multifocal intraocular lenses aim to distribute the energy between the near and far images as a function of the pupil diameter, which in turn varies with the focusing distance. However, the aperture aberrations affect the result and thus such lenses provide little improvement in comparison with less sophisticated designs.11 The accommodative intraocular lens is an alternative solution that relies on the physiological function of the ciliary muscle of the eye after a cataract surgery to produce a forward shift of the intraocular lens. The effectiveness of this technique, however, is still a matter of controversy.12 Clearly, the aged human eye has a need for EDOF and different approaches have already been reported to meet this demand. Unlike the hybrid optodigital EDOF imaging systems, the human eye cannot apply digital deconvolution to the retinal image before the brain processes it. Several diffractive elements with EDOF imaging properties, of radial (e.g., axicons13 and axilens14) and angular (e.g., light sword15) modulation, have been recently considered for presbyopia compensation in aged human vision.16–18