A number of diagnostic modalities for imaging of vascular network are available in clinical and preclinical practice, including x-ray and computer tomography (CT),1 magnetic resonance imaging (MRI),1 Doppler ultrasound,2 laser Doppler blood flowmetry (LDF),3 laser-scanning confocal imaging,4 single photon emission computed tomography (SPECT),5 capillaroscopy,6 optical/fluorescent imaging,7,8 photo-acoustic imaging,9 optical coherence tomography (OCT)10,11 and others.12 However, a noninvasive diagnostic technique for high-resolution in vivo imaging of vascular network, blood flow, and lymph microcirculation is not available for day-to-day medical practice, mainly due to the limitations of the techniques mentioned above. Doppler ultrasound allows tracking flow velocities at different locations in a tissue, however, long acoustic wavelength required for deep-tissue penetration limits spatial resolution to 200 µm. Application of the capillaroscopy technique requires the tissues to be thin enough (less than 400 µm) to be trans-illuminated. Images obtained using laser-scanning confocal microscopy can only be collected at a fraction of the normal video rate. Conventional and magneto resonance angiography provides information mainly on large blood vessels, such as the coronary artery. The disadvantages of OCT and photo-acoustic imaging are their high sensitivity to the unintended movements of the subject of investigation. Inability to monitor flow value in the lymph and blood vessels of 50-µm diameter or smaller with the flow rate less is another drawback. LDF provides only an average characteristic of the skin blood flow, so-called perfusion, as the strong optical scattering in biological tissue significantly restricts visualization of spatially resolved blood vessels and blood flows.