Research Papers: Imaging

Changes in diffusion path length with old age in diffuse optical tomography

[+] Author Affiliations
Clément Bonnéry, Michèle Desjardins

Ecole Polytechnique, Department of Electrical Engineering, C.P. 6079, Succursale Centre-ville, Montréal, Quebec, H3C 3A7, Canada

Paul-Olivier Leclerc, Rick Hoge

Université de Montréal, Department of Physiology, Quebec, Canada

Louis Bherer

UQAM, Department of Psychology, Montréal, Quebec, Canada

Philippe Pouliot, Frédéric Lesage

Ecole Polytechnique, Department of Electrical Engineering, C.P. 6079, Succursale Centre-ville, Montréal, Quebec, H3C 3A7, Canada

Montreal Heart Institute, Research center, Quebec, Canada

J. Biomed. Opt. 17(5), 056002 (May 04, 2012). doi:10.1117/1.JBO.17.5.056002
History: Received January 6, 2012; Revised March 5, 2012; Accepted March 7, 2012
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Abstract.  Diffuse, optical near infrared imaging is increasingly being used in various neurocognitive contexts where changes in optical signals are interpreted through activation maps. Statistical population comparison of different age or clinical groups rely on the relative homogeneous distribution of measurements across subjects in order to infer changes in brain function. In the context of an increasing use of diffuse optical imaging with older adult populations, changes in tissue properties and anatomy with age adds additional confounds. Few studies investigated these changes with age. Duncan et al. measured the so-called diffusion path length factor (DPF) in a large population but did not explore beyond the age of 51 after which physiological and anatomical changes are expected to occur [Pediatr. Res. 39(5), 889–894 (1996)]. With increasing interest in studying the geriatric population with optical imaging, we studied changes in tissue properties in young and old subjects using both magnetic resonance imaging (MRI)-guided Monte-Carlo simulations and time-domain diffuse optical imaging. Our results, measured in the frontal cortex, show changes in DPF that are smaller than previously measured by Duncan et al. in a younger population. The origin of these changes are studied using simulations and experimental measures.

Figures in this Article
© 2012 Society of Photo-Optical Instrumentation Engineers

Topics

Sensors ; Simulations

Citation

Clément Bonnéry ; Paul-Olivier Leclerc ; Michèle Desjardins ; Rick Hoge ; Louis Bherer, et al.
"Changes in diffusion path length with old age in diffuse optical tomography", J. Biomed. Opt. 17(5), 056002 (May 04, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.5.056002


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