Research Papers: Imaging

Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

[+] Author Affiliations
Haixin Ke, Lihong V. Wang

Washington University, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri

Todd N. Erpelding, Ladislav Jankovic

Philips Research North America, Briarcliff Manor, New York

Changjun Liu

Washington University, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri

Sichuan University, School of Electronics and Information Engineering, Chengdu, China

J. Biomed. Opt. 17(5), 056010 (May 04, 2012). doi:10.1117/1.JBO.17.5.056010
History: Received December 19, 2011; Revised March 28, 2012; Accepted March 29, 2012
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Abstract.  We developed a novel trimodality system for human breast imaging by integrating photoacoustic (PA) and thermoacoustic (TA) imaging techniques into a modified commercial ultrasound scanner. Because light was delivered with an optical assembly placed within the microwave antenna, no mechanical switching between the microwave and laser sources was needed. Laser and microwave excitation pulses were interleaved to enable PA and TA data acquisition in parallel at a rate of 10 frames per second. A tube (7 mm inner diameter) filled with oxygenated bovine blood or 30 mM methylene blue dye was successfully detected in PA images in chicken breast tissue at depths of 6.6 and 8.4 cm, respectively, for the first time. The SNRs at these depths reached 24 and 15dB, respectively, by averaging 200 signal acquisitions. Similarly, a tube (13 mm inner diameter) filled with saline solution (0.9%) at a depth of 4.4 cm in porcine fat tissue was successfully detected in TA images. The PA axial, lateral, and elevational resolutions were 640 μm, 720 μm, and 3.5 mm, respectively, suitable for breast cancer imaging. A PA noise-equivalent sensitivity to methylene blue solution of 260 nM was achieved in chicken tissue at a depth of 3.4 cm.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Haixin Ke ; Todd N. Erpelding ; Ladislav Jankovic ; Changjun Liu and Lihong V. Wang
"Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system", J. Biomed. Opt. 17(5), 056010 (May 04, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.5.056010


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