Research Papers: Sensing

Lifetime-based photoacoustic oxygen sensing in vivo

[+] Author Affiliations
Aniruddha Ray

University of Michigan, Biophysics, Ann Arbor, Michigan 48109

Justin Rajesh Rajian, Xueding Wang

University of Michigan, Department of Radiology, Ann Arbor, Michigan 48109

Yong-Eun Koo Lee

University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109

Raoul Kopelman

University of Michigan, Biophysics, Ann Arbor, Michigan 48109

University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109

J. Biomed. Opt. 17(5), 057004 (May 04, 2012). doi:10.1117/1.JBO.17.5.057004
History: Received January 4, 2012; Revised March 16, 2012; Accepted March 29, 2012
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Abstract.  The determination of oxygen levels in blood and other tissues in vivo is critical for ensuring proper body functioning, for monitoring the status of many diseases, such as cancer, and for predicting the efficacy of therapy. Here we demonstrate, for the first time, a lifetime-based photoacoustic technique for the measurement of oxygen in vivo, using an oxygen sensitive dye, enabling real time quantification of blood oxygenation. The results from the main artery in the rat tail indicated that the lifetime of the dye, quantified by the photoacoustic technique, showed a linear relationship with the blood oxygenation levels in the targeted artery.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Topics

Oxygen ; Blood ; Tissues

Citation

Aniruddha Ray ; Justin Rajesh Rajian ; Yong-Eun Koo Lee ; Xueding Wang and Raoul Kopelman
"Lifetime-based photoacoustic oxygen sensing in vivo", J. Biomed. Opt. 17(5), 057004 (May 04, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.5.057004


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