Research Papers: Therapeutic

Fat tissue histological study at indocyanine green-mediated photothermal/photodynamic treatment of the skin in vivo

[+] Author Affiliations
Irina Yu. Yanina

Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskay Str., 410012 Saratov, Russia

Valery V. Tuchin

Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskay Str., 410012 Saratov, Russia

Laboratory of Laser Diagnostics of Technical and Living Systems of Precision Mechanics and Control Institute of the Russian Academy of Sciences, 24 Rabochaya, 410028 Saratov, Russia

University of Oulu, Optoelectronics and Measurement Techniques Laboratory, P.O. Box 4500, FIN-90014 Oulu, Finland

Nikita A. Navolokin, Olga V. Matveeva, Alla B. Bucharskaya, Galina N. Maslyakova

Saratov State Medical University, Department of Pathological Anatomy, 112 B. Kazachaya Str., 410026 Saratov, Russia

Gregory B. Altshuler

Palomar Medical Technologies, Inc., Burlington, Massachusetts

J. Biomed. Opt. 17(5), 058002 (May 07, 2012). doi:10.1117/1.JBO.17.5.058002
History: Received October 15, 2011; Revised February 25, 2012; Accepted March 27, 2012
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Abstract.  Histological slices of skin samples with the subcutaneous adipose tissue after photothermal/photodynamic treatment are analyzed. In the case of subcutaneous indocyanine green injection and 808-nm diode laser exposure of the rat skin site in vivo, the greatest changes in tissue condition were observed. Processes were characterized by dystrophy, necrosis, and desquamation of the epithelial cells, swelling and necrosis of the connective tissue, and widespread necrosis of the subcutaneous adipose tissue. The obtained data are useful for safe layer-by-layer dosimetry of laser illumination of ICG-stained adipose tissue for treatment of obesity and cellulite.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Irina Yu. Yanina ; Valery V. Tuchin ; Nikita A. Navolokin ; Olga V. Matveeva ; Alla B. Bucharskaya, et al.
"Fat tissue histological study at indocyanine green-mediated photothermal/photodynamic treatment of the skin in vivo", J. Biomed. Opt. 17(5), 058002 (May 07, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.5.058002


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