Research Papers: Therapeutic

Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction

[+] Author Affiliations
Florian Rudnitzki, Ramtin Rahmanzadeh, Katrin Brieger

University of Lübeck, Institute of Biomedical Optics, Peter-Monnik-Weg 4, 23562 Lübeck, Germany

Marco Bever

Medical Laser Center Lübeck (MLL) GmbH, Peter-Monnik-Weg 4, 23562 Lübeck, Germany

Elmar Endl

University of Bonn, Institutes of Molecular Medicine and Experimental Immunology, Sigmund-Freud-Straße 25, 53105 Bonn, Germany

Jürgen Groll

University of Würzburg Medical School, Department of Functional Materials in Medicine and Dentistry, Pleicherwall 2, 97070 Würzburg, Germany

Gereon Hüttmann

University of Lübeck, Institute of Biomedical Optics, Peter-Monnik-Weg 4, 23562 Lübeck, Germany

Medical Laser Center Lübeck (MLL) GmbH, Peter-Monnik-Weg 4, 23562 Lübeck, Germany

J. Biomed. Opt. 17(5), 058003 (May 07, 2012). doi:10.1117/1.JBO.17.5.058003
History: Received January 3, 2012; Revised March 20, 2012; Accepted March 27, 2012
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Abstract.  When irradiated with nanosecond laser pulses, gold nanoparticles allow for manipulation or destruction of cells and proteins with high spatial and temporal precision. Gold nanorods are especially attractive, because they have an up-to-20-fold stronger absorption than a sphere of equal volume, which is shifted to the optical window of tissue. Thus, an increased efficiency of cell killing is expected with laser pulses tuned to the near infrared absorption peak of the nanorods. In contrast to the higher-absorption, experiments showed a reduced efficacy of cell killing. In order to explain this discrepancy, transient absorption of irradiated nanorods was measured and the observed change of particle absorption was theoretically analyzed. During pulsed irradiation a strong transient and permanent bleaching of the near-infrared absorption band occurred. Both effects limit the ability of nanorods to destroy cells by nanocavitation. The existence of nanocavitation and transient bleaching was corroborated by optoacoustic measurements.

© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Florian Rudnitzki ; Marco Bever ; Ramtin Rahmanzadeh ; Katrin Brieger ; Elmar Endl, et al.
"Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction", J. Biomed. Opt. 17(5), 058003 (May 07, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.5.058003


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