Special Section on Photoacoustic Imaging and Sensing

Photoacoustic-guided ultrasound therapy with a dual-mode ultrasound array

[+] Author Affiliations
Amaury Prost, Arik Funke, Mickaël Tanter, Jean-François Aubry, Emmanuel Bossy

Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM ERL U979, 10 rue Vauquelin, 75231 Paris Cedex 05, France

J. Biomed. Opt. 17(6), 061205 (May 07, 2012). doi:10.1117/1.JBO.17.6.061205
History: Received August 31, 2011; Revised November 9, 2011; Accepted December 12, 2011
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Abstract.  Photoacoustics has recently been proposed as a potential method to guide and/or monitor therapy based on high-intensity focused ultrasound (HIFU). We experimentally demonstrate the creation of a HIFU lesion at the location of an optical absorber, by use of photoacoustic signals emitted by the absorber detected on a dual mode transducer array. To do so, a dedicated ultrasound array intended to both detect photoacoustic waves and emit HIFU with the same elements was used. Such a dual-mode array provides automatically coregistered reference frames for photoacoustic detection and HIFU emission, a highly desired feature for methods involving guidance or monitoring of HIFU by use of photoacoustics. The prototype is first characterized in terms of both photoacoustic and HIFU performances. The probe is then used to perform an idealized scenario of photoacoustic-guided therapy, where photoacoustic signals generated by an absorbing thread embedded in a piece of chicken breast are used to automatically refocus a HIFU beam with a time-reversal mirror and necrose the tissue at the location of the absorber.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Amaury Prost ; Arik Funke ; Mickaël Tanter ; Jean-François Aubry and Emmanuel Bossy
"Photoacoustic-guided ultrasound therapy with a dual-mode ultrasound array", J. Biomed. Opt. 17(6), 061205 (May 07, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.061205


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