Special Section on Photoacoustic Imaging and Sensing

Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform

[+] Author Affiliations
Wei Song

Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208

Harbin Institute of Technology, Department of Physics, Nangang District, Harbin, Heilongjiang 150080, China

Qing Wei, Tan Liu, David Kuai, Hao F. Zhang

Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208

Janice M. Burke

Medical College of Wisconsin, Department of Ophthalmology, Milwaukee, Wisconsin 53226

Shuliang Jiao

University of Southern California, Department of Ophthalmology, Los Angeles California 90033

J. Biomed. Opt. 17(6), 061206 (May 07, 2012). doi:10.1117/1.JBO.17.6.061206
History: Received September 28, 2011; Revised November 23, 2011; Accepted December 12, 2011
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Abstract.  Photoacoustic ophthalmoscopy (PAOM) is a newly developed retinal imaging technology that holds promise for both fundamental investigation and clinical diagnosis of several blinding diseases. Hence, integrating PAOM with other existing ophthalmic imaging modalities is important to identify and verify the strengths of PAOM compared with the established technologies and to provide the foundation for more comprehensive multimodal imaging. To this end, we developed a retinal imaging platform integrating PAOM with scanning laser ophthalmoscopy (SLO), spectral-domain optical coherence tomography (SD-OCT), and fluorescein angiography (FA). In the system, all the imaging modalities shared the same optical scanning and delivery mechanisms, which enabled registered retinal imaging from all the modalities. High-resolution PAOM, SD-OCT, SLO, and FA images were acquired in both albino and pigmented rat eyes. The reported in vivo results demonstrate the capability of the integrated system to provide comprehensive anatomic imaging based on multiple optical contrasts.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Wei Song ; Qing Wei ; Tan Liu ; David Kuai ; Janice M. Burke, et al.
"Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform", J. Biomed. Opt. 17(6), 061206 (May 07, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.061206


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