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Special Section on Photoacoustic Imaging and Sensing

In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe

[+] Author Affiliations
Yu Wang, Zijian Guo, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, 1 Brookings Drive, St. Louis, Missouri 63130

Todd N. Erpelding, Ladislav Jankovic, Jean-Luc Robert, Guillaume David

Philips Research North America, 345 Scarborough Road, Briarcliff Manor, New York 10510

J. Biomed. Opt. 17(6), 061208 (May 07, 2012). doi:10.1117/1.JBO.17.6.061208
History: Received September 30, 2011; Revised December 14, 2011; Accepted December 19, 2011
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Abstract.  We present an integrated photoacoustic and ultrasonic three-dimensional (3-D) volumetric imaging system based on a two-dimensional (2-D) matrix array ultrasound probe. A wavelength-tunable dye laser pumped by a Q-switched Nd:YAG laser serves as the light source and a modified commercial ultrasound imaging system (iU22, Philips Healthcare) with a 2-D array transducer (X7-2, Philips Healthcare) detects both the pulse-echo ultrasound and photoacoustic signals. A multichannel data acquisition system acquires the RF channel data. The imaging system enables rendering of co-registered 3-D ultrasound and photoacoustic images without mechanical scanning. The resolution along the azimuth, elevation, and axial direction are measured to be 0.69, 0.90 and 0.84 mm for photoacoustic imaging. In vivo 3-D photoacoustic mapping of the sentinel lymph node was demonstrated in a rat model using methylene blue dye. These results highlight the clinical potential of 3-D PA imaging for identification of sentinel lymph nodes for cancer staging in humans.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Yu Wang ; Todd N. Erpelding ; Ladislav Jankovic ; Zijian Guo ; Jean-Luc Robert, et al.
"In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe", J. Biomed. Opt. 17(6), 061208 (May 07, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.061208


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