Special Section on Photoacoustic Imaging and Sensing

Real-time temperature determination during retinal photocoagulation on patients

[+] Author Affiliations
Ralf Brinkmann, Kerstin Schlott, Reginald Birngruber

University of Lübeck, Institute of Biomedical Optics, Lübeck, Germany

Medical Laser Center Lübeck GmbH, Lübeck, Germany

Stefan Koinzer, Johann Roider

University Hospital of Schleswig-Holstein, Department of Ophthalmology, Campus Kiel, Kiel, Germany

Lars Ptaszynski, Marco Bever, Alexander Baade

Medical Laser Center Lübeck GmbH, Lübeck, Germany

Susanne Luft, Yoko Miura

University of Lübeck, Institute of Biomedical Optics, Lübeck, Germany

J. Biomed. Opt. 17(6), 061219 (May 15, 2012). doi:10.1117/1.JBO.17.6.061219
History: Received September 20, 2011; Revised February 8, 2012; Accepted March 5, 2012
Text Size: A A A

Abstract.  The induced thermal damage in retinal photocoagulation depends on the temperature increase and the time of irradiation. The temperature rise is unknown due to intraocular variations in light transmission, scattering and grade of absorption in the retinal pigment epithelium (RPE) and the choroid. Thus, in clinical practice, often stronger and deeper coagulations are applied than therapeutically needed, which can lead to extended neuroretinal damage and strong pain perception. This work focuses on an optoacoustic (OA) method to determine the temperature rise in real-time during photocoagulation by repetitively exciting thermoelastic pressure transients with nanosecond probe laser pulses, which are simultaneously applied to the treatment radiation. The temperature-dependent pressure amplitudes are non-invasively detected at the cornea with an ultrasonic transducer embedded in the contact lens. During clinical treatment, temperature courses as predicted by heat diffusion theory are observed in most cases. For laser spot diameters of 100 and 300 μm, and irradiation times of 100 and 200 ms, respectively, peak temperatures range between 70°C and 85°C for mild coagulations. The obtained data look very promising for the realization of a feedback-controlled treatment, which automatically generates preselected and reproducible coagulation strengths, unburdens the ophthalmologist from manual laser dosage, and minimizes adverse effects and pain for the patient.

Figures in this Article
© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Ralf Brinkmann ; Stefan Koinzer ; Kerstin Schlott ; Lars Ptaszynski ; Marco Bever, et al.
"Real-time temperature determination during retinal photocoagulation on patients", J. Biomed. Opt. 17(6), 061219 (May 15, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.061219


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.