Research Papers: Imaging

In situ gold nanoparticles formation: contrast agent for dental optical coherence tomography

[+] Author Affiliations
Ana K. S. Braz

Federal University of Pernambuco, Graduate Program in Odontology, Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife Pernambuco, CEP: 50670-901, Brazil

Federal University of Pernambuco, Laboratory of Biomedical Optics and Imaging, Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife Pernambuco, CEP: 50670-901, Brazil

Renato E. de Araujo

Federal University of Pernambuco, Laboratory of Biomedical Optics and Imaging, Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife Pernambuco, CEP: 50670-901, Brazil

Tymish Y. Ohulchanskyy, Shoba Shukla, Earl J. Bergey, Paras N. Prasad

University at Buffalo, The Institute for Lasers, Photonics and Biophotonics, 458 Natural Sciences Complex, Buffalo, New York 14260

Anderson S. L. Gomes

Federal University of Pernambuco, Physics Department, Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife Pernambuco, CEP: 50670-901, Brazil

J. Biomed. Opt. 17(6), 066003 (Jun 05, 2012). doi:10.1117/1.JBO.17.6.066003
History: Received December 14, 2011; Revised March 23, 2012; Accepted April 4, 2012
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Abstract.  In this work we demonstrate the potential use of gold nanoparticles as contrast agents for the optical coherence tomography (OCT) imaging technique in dentistry. Here, a new in situ photothermal reduction procedure was developed, producing spherical gold nanoparticles inside dentinal layers and tubules. Gold ions were dispersed in the primer of commercially available dental bonding systems. After the application and permeation in dentin by the modified adhesive systems, the dental bonding materials were photopolymerized concurrently with the formation of gold nanoparticles. The gold nanoparticles were visualized by scanning electron microscopy (SEM). The SEM images show the presence of gold nanospheres in the hybrid layer and dentinal tubules. The diameter of the gold nanoparticles was determined to be in the range of 40 to 120 nm. Optical coherence tomography images were obtained in two- and three-dimensions. The distribution of nanoparticles was analyzed and the extended depth of nanosphere production was determined. The results show that the OCT technique, using in situ formed gold nanoparticles as contrast enhancers, can be used to visualize dentin structures in a non-invasive and non-destructive way.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Ana K. S. Braz ; Renato E. de Araujo ; Tymish Y. Ohulchanskyy ; Shoba Shukla ; Earl J. Bergey, et al.
"In situ gold nanoparticles formation: contrast agent for dental optical coherence tomography", J. Biomed. Opt. 17(6), 066003 (Jun 05, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.066003


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