Research Papers: Imaging

Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system

[+] Author Affiliations
Nathanael Kuo

Johns Hopkins University, Department of Biomedical Engineering, 3400 North Charles Street, Baltimore, Maryland 21218

Hyun Jae Kang

Johns Hopkins University, Department of Computer Science, 3400 North Charles Street, Baltimore, Maryland 21218

Danny Y. Song

Johns Hopkins University, Department of Radiation Oncology, 401 North Broadway, Baltimore, Maryland 21231

Jin U. Kang

Johns Hopkins University, Department of Electrical and Computer Engineering, 3400 North Charles Street, Baltimore, Maryland 21218

Emad M. Boctor

Johns Hopkins University, Department of Radiology, 3400 North Charles Street, Baltimore, Maryland 21218

J. Biomed. Opt. 17(6), 066005 (Jun 04, 2012). doi:10.1117/1.JBO.17.6.066005
History: Received January 13, 2012; Revised April 5, 2012; Accepted April 5, 2012
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Abstract.  Prostate brachytherapy is a popular prostate cancer treatment option that involves the permanent implantation of radioactive seeds into the prostate. However, contemporary brachytherapy procedure is limited by the lack of an imaging system that can provide real-time seed-position feedback. While many other imaging systems have been proposed, photoacoustic imaging has emerged as a potential ideal modality to address this need, since it could easily be incorporated into the current ultrasound system used in the operating room. We present such a photoacoustic imaging system built around a clinical ultrasound system to achieve the task of visualizing and localizing seeds. We performed several experiments to analyze the effects of various parameters on the appearance of brachytherapy seeds in photoacoustic images. We also imaged multiple seeds in an ex vivo dog prostate phantom to demonstrate the possibility of using this system in a clinical setting. Although still in its infancy, these initial results of a photoacoustic imaging system for the application of prostate brachytherapy seed localization are highly promising.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Nathanael Kuo ; Hyun Jae Kang ; Danny Y. Song ; Jin U. Kang and Emad M. Boctor
"Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system", J. Biomed. Opt. 17(6), 066005 (Jun 04, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.066005


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