Research Papers: Imaging

Ultrasound-modulated optical tomography at new depth

[+] Author Affiliations
Puxiang Lai, Xiao Xu, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130

J. Biomed. Opt. 17(6), 066006 (Jun 04, 2012). doi:10.1117/1.JBO.17.6.066006
History: Received March 7, 2012; Revised April 6, 2012; Accepted April 10, 2012
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Abstract.  Ultrasound-modulated optical tomography (UOT) has the potential to reveal optical contrast deep inside soft biological tissues at an ultrasonically determined spatial resolution. The optical imaging depth reported so far has, however, been limited, which prevents this technique from broader applications. Our latest experimental exploration has pushed UOT to an unprecedented imaging depth. We developed and optimized a UOT system employing a photorefractive crystal-based interferometer. A large aperture optical fiber bundle was used to enhance the efficiencies for diffuse light collection and photorefractive two-wave-mixing. Within the safety limits for both laser illumination and ultrasound modulation, the system has attained the ability to image through a tissue-mimicking phantom of 9.4 cm in thickness, which has never been reached previously by UOT.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Puxiang Lai ; Xiao Xu and Lihong V. Wang
"Ultrasound-modulated optical tomography at new depth", J. Biomed. Opt. 17(6), 066006 (Jun 04, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.066006


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