Research Papers: Imaging

Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo

[+] Author Affiliations
Michael Jaeger, Jeffrey Bamber

Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Joint Department of Physics, Sutton, Surrey, SM2 5PT, United Kingdom

Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK-EPSRC Cancer Imaging Centre, Sutton, Surrey, United Kingdom

David Harris-Birtill, Andreas Gertsch

Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Joint Department of Physics, Sutton, Surrey, SM2 5PT, United Kingdom

Elizabeth O’Flynn

Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK-EPSRC Cancer Imaging Centre, Sutton, Surrey, United Kingdom

Royal Marsden NHS Foundation Trust, Radiology Department, Sutton, Surrey, United Kingdom

J. Biomed. Opt. 17(6), 066007 (Jun 04, 2012). doi:10.1117/1.JBO.17.6.066007
History: Received December 22, 2011; Revised April 6, 2012; Accepted April 10, 2012
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Abstract.  Photoacoustic imaging, based on ultrasound detected after laser irradiation, is an extension to diagnostic ultrasound for imaging the vasculature, blood oxygenation and the uptake of optical contrast media with promise for cancer diagnosis. For versatile scanning, the irradiation optics is preferably combined with the acoustic probe in an epi-style arrangement avoiding acoustically dense tissue in the acoustic propagation path from tissue irradiation to acoustic detection. Unfortunately epiphotoacoustic imaging suffers from strong clutter, arising from optical absorption in tissue outside the image plane, and from acoustic backscattering. This limits the imaging depth for useful photoacoustic image contrast to typically less than one centimeter. Deformation-compensated averaging (DCA), which takes advantage of clutter decorrelation induced by palpating the tissue with the imaging probe, has previously been proposed for clutter reduction. We demonstrate for the first time that DCA results in reduced clutter in real-time freehand clinical epiphotoacoustic imaging. For this purpose, combined photoacoustic and pulse-echo imaging at 10-Hz frame rate was implemented on a commercial scanner, allowing for ultrasound-based motion tracking inherently coregistered with photoacoustic frames. Results from the forearm and the neck confirm that contrast is improved and imaging depth increased by DCA.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Michael Jaeger ; David Harris-Birtill ; Andreas Gertsch ; Elizabeth O’Flynn and Jeffrey Bamber
"Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo", J. Biomed. Opt. 17(6), 066007 (Jun 04, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.066007


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