Research Papers: Imaging

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

[+] Author Affiliations
Chao Huang, Liming Nie, Robert W. Schoonover, Zijian Guo, Mark A. Anastasio, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri

Carsten O. Schirra

Philips Research North America, St. Louis, Missouri

J. Biomed. Opt. 17(6), 066016 (Jun 05, 2012). doi:10.1117/1.JBO.17.6.066016
History: Received January 13, 2012; Revised April 9, 2012; Accepted April 12, 2012
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Abstract.  A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Chao Huang ; Liming Nie ; Robert W. Schoonover ; Zijian Guo ; Carsten O. Schirra, et al.
"Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data", J. Biomed. Opt. 17(6), 066016 (Jun 05, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.066016


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