Research Papers: Therapeutic

Effect of low-level laser treatment on cochlea hair-cell recovery after acute acoustic trauma

[+] Author Affiliations
Chung-Ku Rhee, Phil-Sang Chung

Dankook University, Medical Laser Research Center, Cheonan, Republic of Korea

Dankook University, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Cheonan, Republic of Korea

Chan Woong Bahk

Dankook University, Medical Laser Research Center, Cheonan, Republic of Korea

University of Illinois Urbana-Champaign, Champaign, Illinois

Se Hyung Kim

Jeju National University, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Jeju-si, Jeju-do, Republic of Korea

Jin-Chul Ahn, Jae Yun Jung, Myung-Whan Suh

Dankook University, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Cheonan, Republic of Korea

J. Biomed. Opt. 17(6), 068002 (Jun 05, 2012). doi:10.1117/1.JBO.17.6.068002
History: Received November 29, 2011; Revised April 3, 2012; Accepted April 5, 2012
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Abstract.  We investigated the effect of low-level laser radiation on rescuing hair cells of the cochlea after acute acoustic trauma and hearing loss. Nine rats were exposed to noise. Starting the following day, the left ears (NL ears) of the rats were irradiated at an energy output of 100 to 165mW/cm2 for 60 min for 12 days in a row. The right ears (N ears) were considered as the control group. Frequency-specific hearing levels were measured before the noise exposure and also after the 1st, 3rd to 5th, 8th to 10th and 12th irradiations. After the 12th treatment, hair cells were observed using a scanning electron microscope. Compared to initial hearing levels at all frequencies, thresholds increased markedly after noise exposure. After the 12th irradiation, hearing threshold was significantly lower for the NL ears compared to the N ears. When observed using an electron microscope, the number of hair cells in the middle turn of the NL ears was significantly larger than that of the N ears. Our findings suggest that low-level laser irradiation promotes recovery of hearing thresholds after acute acoustic trauma.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Chung-Ku Rhee ; Chan Woong Bahk ; Se Hyung Kim ; Jin-Chul Ahn ; Jae Yun Jung, et al.
"Effect of low-level laser treatment on cochlea hair-cell recovery after acute acoustic trauma", J. Biomed. Opt. 17(6), 068002 (Jun 05, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.068002


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