Research Papers: Therapeutic

New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm

[+] Author Affiliations
Ying Wang, Ying Gu, Naiyan Huang, Haixia Qiu, Jing Zeng, Jianguo Zhu, Jie Liang

Chinese People’s Liberation Army General Hospital, Department of Laser Medicine, Beijing 100853, China

Zhaohui Zuo

Beijing Shuguang Aerospace Electrical Co. Ltd., No. J.5 Jingshun Road, Chaoyang District, Beijing 100028, China

Rong Chen, Buhong Li

Fujian Normal University, Institute of Laser, Key Laboratory of Photonic Technology of Fujian Province, No. 8 Shangshan Road, Cangshan District, Fujzhou 350007, China

J. Biomed. Opt. 17(6), 068003 (Jun 06, 2012). doi:10.1117/1.JBO.17.6.068003
History: Received February 6, 2012; Revised April 19, 2012; Accepted April 27, 2012
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Abstract.  To expand the optional laser wavelengths of photodynamic therapy (PDT) for port wine stain (PWS), the feasibility of applying a 457 nm laser to the PDT for infantile PWS was analyzed by mathematical simulation and was validated by clinical experiment. Singlet oxygen yield of 457 nm PDT or 532 nm PDT in an infantile PWS model and an adult PWS model was theoretically simulated. Fifteen PWS patients (14 infants and 1 adult) with 40 spots were treated with 457 nm (20 spots) and 532 nm (20 spots), respectively, in two PDT courses. Simulation results showed that under the same power density and irradiation time, singlet oxygen yield of 457 nm PDT and 532 nm PDT are similar in infantile PWS vessels. Yet, in adult PWS vessels, singlet oxygen yield of 457 nm PDT is lower than 532 nm PDT. Clinical outcomes showed that no statistic difference existed between 457 nm PDT and 532 nm PDT for infantile PWS. The result of this study suggested that 457 nm wavelength laser has the potential to be applied in PDT for infantile PWS.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Ying Wang ; Zhaohui Zuo ; Ying Gu ; Naiyan Huang ; Rong Chen, et al.
"New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm", J. Biomed. Opt. 17(6), 068003 (Jun 06, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.6.068003


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