Special Section on Optical Diagnostic and Biophotonic Methods from Bench to Bedside

Hand-held optical imager (Gen-2): improved instrumentation and target detectability

[+] Author Affiliations
Jean Gonzalez, Joseph DeCerce, Sarah J. Erickson, Sergio L. Martinez, Annie Nunez, Manuela Roman, Barbara Traub, Cecilia A. Flores, Seigbeh M. Roberts, Estrella Hernandez, Wenceslao Aguirre, Anuradha Godavarty

Florida International University, Department of Biomedical Engineering, Optical Imaging Laboratory, Miami, Florida 33174

Richard Kiszonas

Sylvester Comprehensive Cancer Center, Breast Imaging Division, Miami, Florida 33136

J. Biomed. Opt. 17(8), 081402 (May 15, 2012). doi:10.1117/1.JBO.17.8.081402
History: Received October 13, 2011; Revised February 27, 2012; Accepted March 12, 2012
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Abstract.  Hand-held optical imagers are developed by various researchers towards reflectance-based spectroscopic imaging of breast cancer. Recently, a Gen-1 handheld optical imager was developed with capabilities to perform two-dimensional (2-D) spectroscopic as well as three-dimensional (3-D) tomographic imaging studies. However, the imager was bulky with poor surface contact (30%) along curved tissues, and limited sensitivity to detect targets consistently. Herein, a Gen-2 hand-held optical imager that overcame the above limitations of the Gen-1 imager has been developed and the instrumentation described. The Gen-2 hand-held imager is less bulky, portable, and has improved surface contact (86%) on curved tissues. Additionally, the forked probe head design is capable of simultaneous bilateral reflectance imaging of both breast tissues, and also transillumination imaging of a single breast tissue. Experimental studies were performed on tissue phantoms to demonstrate the improved sensitivity in detecting targets using the Gen-2 imager. The improved instrumentation of the Gen-2 imager allowed detection of targets independent of their location with respect to the illumination points, unlike in Gen-1 imager. The developed imager has potential for future clinical breast imaging with enhanced sensitivity, via both reflectance and transillumination imaging.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Jean Gonzalez ; Joseph DeCerce ; Sarah J. Erickson ; Sergio L. Martinez ; Annie Nunez, et al.
"Hand-held optical imager (Gen-2): improved instrumentation and target detectability", J. Biomed. Opt. 17(8), 081402 (May 15, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.8.081402


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