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Special Section on Optical Diagnostic and Biophotonic Methods from Bench to Bedside

Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy

[+] Author Affiliations
Bertan Hallacoglu, Angelo Sassaroli, Sergio Fantini

Tufts University, Department of Biomedical Engineering, 4 Colby St, Medford, Massachusetts 02155

Michael Wysocki, Elizabeth Guerrero-Berroa, Michal Schnaider Beeri, Vahram Haroutunian

Mount Sinai School of Medicine, One Gustave L. Levy Place, New York 10029

Merav Shaul, Irwin H. Rosenberg

Tufts University, Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts 02111

Aron M. Troen

Hebrew University of Jerusalem, Institute of Biochemistry, Food Science and Nutrition, P.O.Box 12, Rehovot 76100, Israel

J. Biomed. Opt. 17(8), 081406 (May 14, 2012). doi:10.1117/1.JBO.17.8.081406
History: Received January 14, 2012; Revised March 13, 2012; Accepted March 22, 2012
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Abstract  We present near-infrared spectroscopy measurement of absolute cerebral hemoglobin concentration and saturation in a large sample of 36 healthy elderly (mean age, 85±6years) and 19 young adults (mean age, 28±4years). Non-invasive measurements were obtained on the forehead using a commercially available multi-distance frequency-domain system and analyzed using a diffusion theory model for a semi-infinite, homogeneous medium with semi-infinite boundary conditions. Our study included repeat measurements, taken five months apart, on 16 elderly volunteers that demonstrate intra-subject reproducibility of the absolute measurements with cross-correlation coefficients of 0.9 for absorption coefficient (μa), oxy-hemoglobin concentration ([HbO2]), and total hemoglobin concentration ([HbT]), 0.7 for deoxy-hemoglobin concentration ([Hb]), 0.8 for hemoglobin oxygen saturation (StO2), and 0.7 for reduced scattering coefficient (μs). We found significant differences between the two age groups. Compared to young subjects, elderly subjects had lower cerebral [HbO2], [Hb], [HbT], and StO2 by 10±4μM, 4±3μM, 14±5μM, and 6%±5%, respectively. Our results demonstrate the reliability and robustness of multi-distance near-infrared spectroscopy measurements based on a homogeneous model in the human forehead on a large sample of human subjects. Absolute, non-invasive optical measurements on the brain, such as those presented here, can significantly advance the development of NIRS technology as a tool for monitoring resting/basal cerebral perfusion, hemodynamics, oxygenation, and metabolism.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Bertan Hallacoglu ; Angelo Sassaroli ; Michael Wysocki ; Elizabeth Guerrero-Berroa ; Michal Schnaider Beeri, et al.
"Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy", J. Biomed. Opt. 17(8), 081406 (May 14, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.8.081406


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