Research Papers: General

Noninvasive optical quantification of absolute blood flow, blood oxygenation, and oxygen consumption rate in exercising skeletal muscle

[+] Author Affiliations
Katelyn Gurley, Yu Shang, Guoqiang Yu

University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky 40506

J. Biomed. Opt. 17(7), 075010 (Jul 12, 2012). doi:10.1117/1.JBO.17.7.075010
History: Received March 28, 2012; Revised June 11, 2012; Accepted June 13, 2012
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Abstract.  This study investigates a method using novel hybrid diffuse optical spectroscopies [near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS)] to obtain continuous, noninvasive measurement of absolute blood flow (BF), blood oxygenation, and oxygen consumption rate (V˙O2) in exercising skeletal muscle. Healthy subjects (n=9) performed a handgrip exercise to increase BF and V˙O2 in forearm flexor muscles, while a hybrid optical probe on the skin surface directly monitored oxy-, deoxy-, and total hemoglobin concentrations ([HbO2], [Hb], and THC), tissue oxygen saturation (StO2), relative BF (rBF), and relative oxygen consumption rate (rV˙O2). The rBF and rV˙O2 signals were calibrated with absolute baseline BF and V˙O2 obtained through venous and arterial occlusions, respectively. Known problems with muscle-fiber motion artifacts in optical measurements during exercise were mitigated using a novel gating algorithm that determined muscle contraction status based on control signals from a dynamometer. Results were consistent with previous findings in the literature. This study supports the application of NIRS/DCS technology to quantitatively evaluate hemodynamic and metabolic parameters in exercising skeletal muscle and holds promise for improving diagnosis and treatment evaluation for patients suffering from diseases affecting skeletal muscle and advancing fundamental understanding of muscle and exercise physiology.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Katelyn Gurley ; Yu Shang and Guoqiang Yu
"Noninvasive optical quantification of absolute blood flow, blood oxygenation, and oxygen consumption rate in exercising skeletal muscle", J. Biomed. Opt. 17(7), 075010 (Jul 12, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.7.075010


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