Research Papers: Sensing

Reproducibility of near-infrared spectroscopy parameters measured during brachial artery occlusion and reactive hyperemia in healthy men

[+] Author Affiliations
Sébastien Lacroix, Mathieu Gayda, Martin Juneau, Anil Nigam

Montreal Heart Institute Montreal, Cardiovascular Rehabilitation and Prevention Centre (ÉPIC), Quebec, Canada

Université de Montréal, Faculty of Medicine, Montreal, Canada

Montreal Heart Institute, Research Center, Montreal, Quebec, Canada

Vincent Gremeaux

Montreal Heart Institute Montreal, Cardiovascular Rehabilitation and Prevention Centre (ÉPIC), Quebec, Canada

Université de Montréal, Faculty of Medicine, Montreal, Canada

Cognition, action and sensorimotor plasticity, Inserm U1093, Dijon, France

Technological Investigation platform, Inserm CIC-P 803, CHU Dijon, France

Reeducation-readaptation pole, CHU Dijon, France

Jean-Claude Tardif

Université de Montréal, Faculty of Medicine, Montreal, Canada

Montreal Heart Institute, Research Center, Montreal, Quebec, Canada

J. Biomed. Opt. 17(7), 077010 (Jul 17, 2012). doi:10.1117/1.JBO.17.7.077010
History: Received April 11, 2012; Revised June 1, 2012; Accepted June 18, 2012
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Abstract.  Near-infrared spectroscopy (NIRS) is a noninvasive technique evaluating microvascular function. The aim of this study was to assess the reproducibility of NIRS parameters during reactive hyperemia induced by a 5 min brachial artery occlusion. Twenty-four healthy young males (mean 34±8 years old) had two microvascular function evaluations by NIRS over a 7 to 30-day period (mean 16±10 days). Intra-subject and inter-observer reproducibility were evaluated with intraclass correlation coefficient (ICC), coefficient of variation (CV), and standard error of measurement (SEM%) for every parameter. Mean NIRS parameters did not differ between both evaluations. Reproducibility was greatest for muscle oxygen consumption (ICC: 0.84; CV: 6.51%; SEM: 7.11%), time to basal O2Hb (ICC: 0.63, CV: 20.04%, SEM 27.22%), time to maximal O2Hb (ICC: 0.71; CV: 15.61%; SEM: 19.27%), peak of O2Hb (ICC: 0.63, CV: 6.68%, SEM 8.53%), time to maximal tHb (ICC: 0.73, CV: 19,61%, SEM 24.56%) and area under the O2Hb and tHb curves (ICC: 0.68, CV: 16.15%, SEM 22.93% and ICC: 0.62, CV: 18.59%, SEM 26.64%, respectively). Moreover, inter-observer reproducibility ranged from excellent to perfect (ICC from 0.85 to 1.00) for every parameter. NIRS parameters during reactive hyperemia are highly reproducible which enables their repeated measurement to study microvascular function in healthy subjects.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Sébastien Lacroix ; Mathieu Gayda ; Vincent Gremeaux ; Martin Juneau ; Jean-Claude Tardif, et al.
"Reproducibility of near-infrared spectroscopy parameters measured during brachial artery occlusion and reactive hyperemia in healthy men", J. Biomed. Opt. 17(7), 077010 (Jul 17, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.7.077010


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