Research Papers: General

Effect of tissue fluid on accurate determination of the complex refractive index of animal tissue

[+] Author Affiliations
Jin Wang, Qing Ye, Zhi-Chao Deng, Wen-Yuan Zhou, Teng-Qian Sun, Chun-Ping Zhang, Jian-Guo Tian

Nankai University, The Key Laboratory of Weak-Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Applied Physics School, Tianjin 300071, China

J. Biomed. Opt. 17(7), 075011 (Jul 17, 2012). doi:10.1117/1.JBO.17.7.075011
History: Received December 12, 2011; Revised June 20, 2012; Accepted June 21, 2012
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Abstract.  We investigate the effect of tissue fluid on the measurement of complex refractive index (RI) of animal tissue. A new model is proposed and verified through experimental results of simulation samples made of glycerol and methyl-red-doped poly(methyl methacrylate). Coupled with polarized optical reflectance measurements performed on several kinds of animal muscle tissues, RIs were resolved using the new model. We find that the tissue fluid existing at the prism-sample interface is unavoidable. We also find that with a change of proportion of the tissue fluid, the RI of muscle tissue can still be measured using the new model.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Jin Wang ; Qing Ye ; Zhi-Chao Deng ; Wen-Yuan Zhou ; Teng-Qian Sun, et al.
"Effect of tissue fluid on accurate determination of the complex refractive index of animal tissue", J. Biomed. Opt. 17(7), 075011 (Jul 17, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.7.075011


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