Research Papers: Imaging

Frequency domain multiplexing for speckle reduction in optical coherence tomography

[+] Author Affiliations
Gijs van Soest, Evelyn Regar

Thorax Center, Erasmus MC, Rotterdam, The Netherlands

Martin Villiger, Guillermo J. Tearney, Brett E. Bouma

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts

Antonius F. W. van der Steen

Thorax Center, Erasmus MC, Rotterdam, The Netherlands

Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands

J. Biomed. Opt. 17(7), 076018 (Jul 13, 2012). doi:10.1117/1.JBO.17.7.076018
History: Received March 21, 2012; Revised May 31, 2012; Accepted June 14, 2012
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Abstract.  Quantitative analysis of optical coherence tomography data can be strongly hampered by speckle. Here, we introduce a new method to reduce speckle, which leverages from Fourier-domain configurations and operates on individual axial scans. By subdividing the digitized spectrum into a number of distinct narrower windows, each with a different center frequency, several independent speckle patterns result. These can be averaged to yield a lower-resolution image with strongly reduced speckle. The full resolution image remains available for human interpretation; the low resolution version can be used for parametric imaging or quantitative analysis. We demonstrate this technique using intravascular optical frequency domain imaging data acquired in vivo.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Gijs van Soest ; Martin Villiger ; Evelyn Regar ; Guillermo J. Tearney ; Brett E. Bouma, et al.
"Frequency domain multiplexing for speckle reduction in optical coherence tomography", J. Biomed. Opt. 17(7), 076018 (Jul 13, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.7.076018


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