0
Special Section on Pioneers in Biomedical Optics: F.F. Jöbsis

Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications

[+] Author Affiliations
Martin Wolf

University Hospital Zurich, Clinic of Neonatology, Biomedical Optics Research Laboratory, 8091 Zurich, Switzerland

Marco Ferrari, Valentina Quaresima

University of L’Aquila, Department of Sciences and Biomedical Technologies, L’Aquila, 67100 Italy

J. Biomed. Opt. 12(6), 062104 (November 15, 2007). doi:10.1117/1.2804899
History: Received March 15, 2007; Revised May 17, 2007; Accepted May 30, 2007; Published November 15, 2007
Text Size: A A A

This review celebrates the 30th anniversary of the first in vivo near-infrared (NIR) spectroscopy (NIRS) publication, which was authored by Professor Frans Jöbsis. At first, NIRS was utilized to experimentally and clinically investigate cerebral oxygenation. Later it was applied to study muscle oxidative metabolism. Since 1993, the discovery that the functional activation of the human cerebral cortex can be explored by NIRS has added a new dimension to the research. To obtain simultaneous multiple and localized information, a further major step forward was achieved by introducing NIR imaging (NIRI) and tomography. This review reports on the progress of the NIRS and NIRI instrumentation for brain and muscle clinical applications 30 years after the discovery of in vivo NIRS. The review summarizes the measurable parameters in relation to the different techniques, the main characteristics of the prototypes under development, and the present commercially available NIRS and NIRI instrumentation. Moreover, it discusses strengths and limitations and gives an outlook into the “bright” future.

© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Martin Wolf ; Marco Ferrari and Valentina Quaresima
"Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications", J. Biomed. Opt. 12(6), 062104 (November 15, 2007). ; http://dx.doi.org/10.1117/1.2804899


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
 
Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement


Buy this article ($18 for members, $25 for non-members).
Sign In