Special Section on Pioneers in Biomedical Optics: F.F. Jöbsis

Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging

[+] Author Affiliations
Huijuan Zhao

Tianjin University, State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin 3000072, China and Tianjin University, College of Precision Instrument and Optoelectronics Engineering, Tianjin 3000072, China

Feng Gao

Tianjin University, College of Precision Instrument and Optoelectronics Engineering, Tianjin 3000072, China

Yukari Tanikawa

National Institute of Advanced Industrial Science and Technology, 1-2 Namiki, Tsukuba, Ibaraki 305-8564, Japan

Yukio Yamada

University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan

J. Biomed. Opt. 12(6), 062107 (November 28, 2007). doi:10.1117/1.2815724
History: Received February 08, 2007; Revised June 22, 2007; Accepted July 16, 2007; Published November 28, 2007
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This work reviews our research during the past several years on time-resolved (TR) near-infrared diffuse optical tomography (DOT). Following an introduction of the measuring modes, two proposed schemes of image reconstruction in TR-DOT are described: one utilizes the full TR data, and the other, referred to as the modified generalized pulse spectrum technique (GPST), uses the featured data extracted from the TR measurement. The performances of the two algorithms in quantitativeness and spatial resolution are comparatively investigated with 2-D simulated data. TR-DOT images are then presented for phantom experiments, which are obtained by using a 16-channel time-correlated single photon counting system, and the factors affecting the quantification of the reconstruction are discussed. Finally, in vitro and in vivo imaging examples are illustrated for validating the capibility of TR-DOT to provide not only the anatomical but also the physiological information of the objects.

© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Huijuan Zhao ; Feng Gao ; Yukari Tanikawa and Yukio Yamada
"Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging", J. Biomed. Opt. 12(6), 062107 (November 28, 2007). ; http://dx.doi.org/10.1117/1.2815724


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