Special Section on Pioneers in Biomedical Optics: F.F. Jöbsis

Comparison of blood-oxygen-level–dependent functional magnetic resonance imaging and near-infrared spectroscopy recording during functional brain activation in patients with stroke and brain tumors

[+] Author Affiliations
Kaoru Sakatani

Nihon University School of Medicine, Division of Optical Brain Engineering and Division of Applied System Neuroscience, Department of Neurosurgery, Tokyo, Japan

Yoshihiro Murata, Norio Fujiwara, Tatsuya Hoshino, Shin Nakamura, Tsuneo Kano

Nihon University School of Medicine, Department of Neurosurgery, Tokyo, Japan

Yoichi Katayama

Nihon University School of Medicine, Division of Applied System Neuroscience, Department of Neurosurgery, Tokyo, Japan

J. Biomed. Opt. 12(6), 062110 (December 28, 2007). doi:10.1117/1.2823036
History: Received March 06, 2007; Revised June 12, 2007; Accepted June 12, 2007; Published December 28, 2007
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Blood-oxygen-level–dependent contrast functional magnetic resonance imaging (BOLD-fMRI) has been used to perform functional imaging in brain disorders such as stroke and brain tumors. However, recent studies have revealed that BOLD-fMRI does not image activation areas correctly in such patients. To clarify the characteristics of the evoked cerebral blood oxygenation (CBO) changes occurring in stroke and brain tumors, we have been comparing near-infrared spectroscopy (NIRS) and BOLD-fMRI recording during functional brain activation in these patients. We review our recent studies and related functional imaging studies on the brain disorders. In the primary sensorimotor cortex (PSMC) on the nonlesion side, the motor task consistently caused a decrease of deoxyhemoglobin (deoxy-Hb) with increases of oxyhemoglobin (oxy-Hb) and total hemoglobin (t-Hb), which is consistent with the evoked CBO response observed in normal adults. BOLD-fMRI demonstrated robust activation areas on the nonlesion side. In stroke patients, severe cerebral ischemia (i.e., misery perfusion) caused an increase of deoxy-Hb during the task, associated with increases of oxy-Hb and t-Hb, in the PSMC on the lesion side. In addition, the activation volume of BOLD-fMRI was significantly reduced on the lesion side. The BOLD signal did not change in some areas of the PSMC on the lesion side, but it tended to decrease in other areas during the tasks. In brain tumors, BOLD-fMRI clearly demonstrated activation areas in the PSMC on the lesion side in patients who displayed a normal evoked CBO response. However, the activation volume on the lesion side was significantly reduced in patients who exhibited an increase of deoxy-Hb during the task. In both stroke and brain tumors, false-negative activations (i.e., marked reductions of activation volumes) in BOLD imaging were associated with increases of deoxy-Hb, which could cause a reduction in BOLD signal. BOLD-fMRI investigations of patients with brain disorders should be performed while giving consideration to atypical evoked CBO changes.

© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Kaoru Sakatani ; Yoshihiro Murata ; Norio Fujiwara ; Tatsuya Hoshino ; Shin Nakamura, et al.
"Comparison of blood-oxygen-level–dependent functional magnetic resonance imaging and near-infrared spectroscopy recording during functional brain activation in patients with stroke and brain tumors", J. Biomed. Opt. 12(6), 062110 (December 28, 2007). ; http://dx.doi.org/10.1117/1.2823036


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