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Research Papers

Core-shell silica nanoparticles as fluorescent labels for nanomedicine

[+] Author Affiliations
Jinhyang Choi

Cornell University, Department of Biomedical Sciences, Ithaca, New York 14853

Andrew A. Burns

Cornell University, Department of Materials Science and Engineering, Ithaca, New York 14853

Rebecca M. Williams

Cornell University, Department of Applied and Engineering Physics, Ithaca, New York 14853

Zongxiang Zhou, Andrea Flesken-Nikitin

Cornell University, Department of Biomedical Sciences, Ithaca, New York 14853

Warren R. Zipfel

Cornell University, Department of Biomedical Engineering, Ithaca, New York 14853

Ulrich Wiesner

Cornell University, Department of Materials Science and Engineering, Ithaca, New York 14853

Alexander Y. Nikitin

Cornell University, Department of Biomedical Sciences, Ithaca, New York 14853

J. Biomed. Opt. 12(6), 064007 (April 17, 2007June 19, 2007July 25, 2007December 28, 2007). doi:10.1117/1.2823149
History: Received April 17, 2007; Revised June 19, 2007; Accepted July 25, 2007; Published December 28, 2007
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Progress in biomedical imaging depends on the development of probes that combine low toxicity with high sensitivity, resolution, and stability. Toward that end, a new class of highly fluorescent core-shell silica nanoparticles with narrow size distributions and enhanced photostability, known as C dots, provide an appealing alternative to quantum dots. Here, C dots are evaluated with a particular emphasis on in-vivo applications in cancer biology. It is established that C dots are nontoxic at biologically relevant concentrations, and can be used in a broad range of imaging applications including intravital visualization of capillaries and macrophages, sentinel lymph node mapping, and peptide-mediated multicolor cell labeling for real-time imaging of tumor metastasis and tracking of injected bone marrow cells in mice. These results demonstrate that fluorescent core-shell silica nanoparticles represent a powerful novel imaging tool within the emerging field of nanomedicine.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Jinhyang Choi ; Andrew A. Burns ; Rebecca M. Williams ; Zongxiang Zhou ; Warren R. Zipfel, et al.
"Core-shell silica nanoparticles as fluorescent labels for nanomedicine", J. Biomed. Opt. 12(6), 064007 (April 17, 2007June 19, 2007July 25, 2007December 28, 2007). ; http://dx.doi.org/10.1117/1.2823149


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