Research Papers

Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

[+] Author Affiliations
Chau-Chung Wu

National Taiwan University, Department of Primary Care Medicine and Department of Internal Medicine, Taipei, Taiwan

Yih-Ming Wang

National Taiwan University, Graduate Institute of Electro-Optical Engineering, Taipei, Taiwan

Long-Sheng Lu

National Taiwan University, Graduate Institute of Pharmacology, Taipei, Taiwan

Chia-Wei Sun

Industrial Technology Research Institute, Medical Electronics and Device Technology Center, Hsinchu, Taiwan

Chih-Wei Lu, Meng-Tsan Tsai, C. C. Yang

National Taiwan University, Graduate Institute of Electro-Optical Engineering and Department of Electrical Engineering, Taipei, Taiwan

J. Biomed. Opt. 12(6), 064022 (November 16, 2007). doi:10.1117/1.2812647
History: Received September 26, 2006; Revised June 20, 2007; Accepted July 17, 2007; Published November 16, 2007
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We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48×104 at 790nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.

© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Chau-Chung Wu ; Yih-Ming Wang ; Long-Sheng Lu ; Chia-Wei Sun ; Chih-Wei Lu, et al.
"Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography", J. Biomed. Opt. 12(6), 064022 (November 16, 2007). ; http://dx.doi.org/10.1117/1.2812647


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