Research Papers: Imaging

Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography

[+] Author Affiliations
Martin Biallas, Ivo Trajkovic

University Hospital Zurich, Biomedical Optics Research Laboratory, Division of Neonatology, CH-8091 Zurich, Switzerland

University of Zurich and ETH Zurich, Institute for Biomedical Engineering, CH-8093 Zurich, Switzerland

Cornelia Hagmann, Felix Scholkmann, Carmen Jenny, Martin Wolf

University Hospital Zurich, Biomedical Optics Research Laboratory, Division of Neonatology, CH-8091 Zurich, Switzerland

Lisa Holper

University Hospital Zurich, Biomedical Optics Research Laboratory, Division of Neonatology, CH-8091 Zurich, Switzerland

University of Zurich and ETH Zurich, Institute of Neuroinformatics, CH-8057 Zurich, Switzerland

Andreas Beck

University of Basel, Core Program of Structural Biology and Biophysics, Biozentrum, CH-4056 Basel, Switzerland

J. Biomed. Opt. 17(8), 086011 (Aug 17, 2012). doi:10.1117/1.JBO.17.8.086011
History: Received December 5, 2011; Revised July 15, 2012; Accepted July 19, 2012
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Abstract.  In this study 14 healthy term newborns (postnatal mean age 2.1 days) underwent photic stimulation during sleep on two different days. Near-infrared spectroscopy (NIRS) and electroencephalography (EEG) was acquired simultaneously. The aims of the study were: to determine (i) the sensitivity and (ii) the repeatability of NIRS to detect the hemodynamic response, (iii) the sensitivity and (iv) the repeatability of EEG to detect a visual evoked potential (VEP), (v) to analyze optical data for the optical neuronal signal, and (vi) to test whether inadequate stimulation could be reason for absent hemodynamic responses. The results of the study were as follows. (i) Sensitivity of NIRS was 61.5% to detect hemodynamic responses; (ii) their reproducibility was 41.7%. A VEP was detected (iii) in 96.3% of all subjects with (iv) a reproducibility of 92.3%. (v) In two measurements data met the criteria for an optical neuronal signal. The noise level was 9.6·105% change in optical density. (vi) Insufficient stimulation was excluded as reason for absent hemodynamic responses. We conclude that NIRS is an promising tool to study cognitive activation and development of the brain. For clinical application, however, the sensitivity and reproducibility on an individual level needs to be improved.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Martin Biallas ; Ivo Trajkovic ; Cornelia Hagmann ; Felix Scholkmann ; Carmen Jenny, et al.
"Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography", J. Biomed. Opt. 17(8), 086011 (Aug 17, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.8.086011


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