Special Section on Selected Topics in Biophotonics: Optical Coherence Tomography and Medical Imaging Using Diffuse Optics

Endoscopic optical coherence tomography device for forward imaging with broad field of view

[+] Author Affiliations
Anke Burkhardt, Julia Walther, Peter Cimalla, Mirko Mehner, Edmund Koch

Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Department of Clinical Sensoring and Monitoring, Fetscherstr. 74, 01307 Dresden, Germany

J. Biomed. Opt. 17(7), 071302 (May 16, 2012). doi:10.1117/1.JBO.17.7.071302
History: Received September 30, 2011; Revised November 29, 2011; Accepted December 5, 2011
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Abstract.  One current challenge of studying human tympanic membranes (TM) with optical coherence tomography (OCT) is the implementation of optics that avoid direct contact with the inflamed tissue. At the moment, no commercial device is available. We report an optics design for contactless forward imaging endoscopic optical coherence tomography (EOCT) with a large working distance (WD) and a broad field of view (FOV) by restricting the overall diameter of the probe to be small (3.5 mm), ensuring a sufficient numerical aperture. Our system uses a gradient-index (GRIN) relay lens and a GRIN objective lens, and executes a fan-shaped optical scanning pattern. The WD and FOV can be adjusted by manually changing the distance between the triplet and the GRIN relay lens. The measured lateral resolution is 28μm at a WD of 10 mm with a FOV of 10 mm. Additionally, a camera and an illumination beam path were implemented within the probe for image guidance during investigations of the TM. We demonstrated the performance of the EOCT design by 3-D imaging of a human TM ex vivo and in vivo with a k-linear spectral domain OCT system.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Anke Burkhardt ; Julia Walther ; Peter Cimalla ; Mirko Mehner and Edmund Koch
"Endoscopic optical coherence tomography device for forward imaging with broad field of view", J. Biomed. Opt. 17(7), 071302 (May 16, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.7.071302


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